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Author Notes:

Dr. C. Ross Ethier (ross.ethier@bme.gatech.edu).

The authors gratefully acknowledge Dr. Jonathan Suever for sharing his Matlab elliptic harmonic code; Dr Michael Drakapoulos from Diamond for advice on conducting the PC μCT experiments; and Mr. Anirudh Joshi for his help with the reconstructions.

Subjects:

Research Funding:

The project was supported by grants from the Science & Technology Facilities Council EE8491, EE9825 and EE11407; and by funding from the Georgia Research Alliance (CRE).

Keywords:

  • Science & Technology
  • Technology
  • Life Sciences & Biomedicine
  • Computer Science, Interdisciplinary Applications
  • Engineering, Biomedical
  • Engineering, Electrical & Electronic
  • Imaging Science & Photographic Technology
  • Radiology, Nuclear Medicine & Medical Imaging
  • Computer Science
  • Engineering
  • Biomechanics
  • strain measurements
  • x-ray tomography
  • OPTIC-NERVE HEAD
  • DIGITAL VOLUME CORRELATION
  • OPEN-ANGLE GLAUCOMA
  • COHERENCE TOMOGRAPHY
  • CONNECTIVE-TISSUE
  • HUMAN EYES
  • STRAIN
  • BONE
  • BIOMECHANICS
  • ELEVATION

Phase-Contrast Micro-Computed Tomography Measurements of the Intraocular Pressure-Induced Deformation of the Porcine Lamina Cribrosa

Tools:

Journal Title:

IEEE Transactions on Medical Imaging

Volume:

Volume 35, Number 4

Publisher:

, Pages 988-999

Type of Work:

Article | Post-print: After Peer Review

Abstract:

The lamina cribrosa (LC) is a complex mesh-like tissue in the posterior eye. Its biomechanical environment is thought to play a major role in glaucoma, the second most common cause of blindness. Due to its small size and relative inaccessibility, high-resolution measurements of LC deformation, important in characterizing LC biomechanics, are challenging. Here we present a novel noninvasive imaging method, which enables measurement of the three-dimensional deformation of the LC caused by acute elevation of intraocular pressure (IOP). Posterior segments of porcine eyes were imaged using synchrotron radiation phase contrast micro-computed tomography (PC μCT) at IOPs between 6 and 37 mmHg. The complex trabecular architecture of the LC was reconstructed with an isotropic spatial resolution of 3.2 μm. Scans acquired at different IOPs were analyzed with digital volume correlation (DVC) to compute full-field deformation within the LC. IOP elevation caused substantial tensile, shearing and compressive devformation within the LC, with maximum tensile strains at 30 mmHg averaging 5.5%, and compressive strains reaching 20%. We conclude that PC μCT provides a novel high-resolution method for imaging the LC, and when combined with DVC, allows for full-field 3D measurement of ex vivo LC biomechanics at high spatial resolution.

Copyright information:

© 2015 IEEE.

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