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Author Notes:

Address correspondence to: Monica Uddin, PhD, 3103 Carl R. Woese Institute for Genomic Biology, MC-195, 1206 West Gregory Drive, Urbana, IL 61801, Ph: (217) 300-0937, muddin@illinois.edu

Subjects:

Research Funding:

This work was supported by NIH grants R01MH108826 and R01MH106595, and the University of Illinois’ CompGen Initiative.

Keywords:

  • Science & Technology
  • Life Sciences & Biomedicine
  • Biochemistry & Molecular Biology
  • Neurosciences
  • Neurosciences & Neurology
  • GLUCOCORTICOID-RECEPTOR GENE
  • ANTERIOR CINGULATE CORTEX
  • GENOME-WIDE ASSOCIATION
  • GYRUS GRANULE NEURONS
  • ANIMAL-MODEL
  • DNA METHYLATION
  • FEAR-EXTINCTION
  • EPIGENETIC MECHANISMS
  • PREFRONTAL CORTEX
  • TRAUMATIC STRESS

Neuroepigenetics of Post-Traumatic Stress Disorder

Tools:

Journal Title:

Progress in Molecular Biology and Translational Science

Volume:

Volume 158

Publisher:

, Pages 227-253

Type of Work:

Article | Post-print: After Peer Review

Abstract:

While diagnosis of PTSD is based on behavioral symptom clusters that are most directly associated with brain function, epigenetic studies of PTSD in humans to date have been limited to peripheral tissues. Animal models of PTSD have been key for understanding the epigenetic alterations in the brain most directly relevant to endophenotypes of PTSD, in particular those pertaining to fear memory and stress response. This chapter provides an overview of neuroepigenetic studies based on animal models of PTSD, with an emphasis on the effect of stress on fear memory. Where relevant, we also describe human-based studies with relevance to neuroepigenetic insights gleaned from animal work and suggest promising directions for future studies of PTSD neuroepigenetics in living humans that combine peripheral epigenetic measures with measures of central nervous system activity, structure and function.

Copyright information:

© 2018 Elsevier Inc.

This is an Open Access work distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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