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Correspondence to: N Rivard, Department of Anatomy and Cell Biology, Cancer Research Pavilion, Faculty of Medicine and Health Sciences, Université de Sherbrooke, 3201 rue Jean Mignault, Sherbrooke, QC J1E4K8, Canada. E‐mail: nathalie.rivard@usherbrooke.ca
G‐S performed most of the research shown in Figures 1, ,2,2, ,3,3, ,4,4, ,5,5, ,66 and in supplementary material, Figure S2.
GC performed the experiments shown in supplementary material, Figure S1, while AL performed experiments shown in some panels of Figures 4 and and55 and in supplementary material, Figure S2.
VV‐L and M‐JL helped with the handling of mice and cell lines.
M‐JL also contributed to the organoid experiments shown in Figure 6.
CKQ provided Ptpn11 E76KNeo/+ mice and revised the manuscript.
ST and AM designed the experiments shown in Figure 3D–G (C. rodentium infection) and revised the manuscript.
JG‐S, M‐JL and NR wrote the paper.
NR was in charge of overall direction and planning.
All authors read and approved the final manuscript.
We thank Pr Claude Asselin for critical reading of the manuscript.
We thank the RNomics and Electron Microscopy & Histology Platforms of the FMSS at the Université de Sherbrooke for services.
Special thanks to Drs David Dankort (McGill University) and Martin McMahon (University of Utah Health Sciences) for providing Braf V600E mice and to Dr Daniel Podolsky (UT Southwestern Medical Center) for sharing a Tff3 antibody.
No conflicts of interest were declared.
This research was supported by a grant from Canadian Institutes of Health Research (CIHR) to Nathalie Rivard.
Jessica Gagné‐Sansfaçon is a FRQS student scholar.
Nathalie Rivard and Alfredo Menendez are members of the FRQS‐Funded Centre de Recherche du CHUS.
Nathalie Rivard is a recipient of a Canadian Research Chair in colorectal cancer and inflammatory cell signaling.
© 2018 The Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of Pathological Society of Great Britain and Ireland.