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Author Notes:

Delynn M. Moss, Division of Foodborne, Waterborne, and Environmental Diseases, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA, E-mail: dmm3@cdc.gov

Or Sukwan Handali, Division of Parasitic Diseases and Malaria, Centers for Disease Control and Prevention, 1600 Clifton Rd., Atlanta, GA 30329, E-mail: ahi0@cdc.gov.

We would like to thank the parents, students, and teachers who allowed us to conduct this work, and the Government of Mali.

We would also like to thank the research team, including Abdoulaye Sow; Seydou Samaké; Salif Ismaïla Traoré; Fatoumata Habib Traoré; Karim Diamoutene; Yacouba Sogore; Alpha Oumar Haidara; and Niélé Hawa Diarra and Samba Diop from the University of Bamako.

We also thank the UNICEF; WaterAid; CARE; Oxfam; and Save the Children teams for their support; specifically Jérémie Toubkiss, Yagouba Diallo; Seydou Niafo; Touréba Keïta; Assitan Sogoré; Salimata Togola; Fatoumata Haïdara; Mamadou Diallo; Zoumana Cissé Ousmane Haïdara; and Thierno Bocoum.

Subjects:

Keywords:

  • Science & Technology
  • Life Sciences & Biomedicine
  • Public, Environmental & Occupational Health
  • Tropical Medicine
  • NEUROCYSTICERCOSIS
  • DIAGNOSIS
  • IMPACT

Detection of Immunoglobulin G Antibodies to Taenia solium Cysticercosis Antigen Glutathione-S-Transferase-rT24H in Malian Children Using Multiplex Bead Assay

Tools:

Journal Title:

American Journal of Tropical Medicine and Hygiene

Volume:

Volume 98, Number 5

Publisher:

, Pages 1408-1412

Type of Work:

Article | Final Publisher PDF

Abstract:

Blood samples from 805 students attending 42 elementary schools in Mopti, Sikasso, and Koulikoro regions, and Bamako district in Mali participated in a school water, sanitation, and hygiene intervention. Immunoglobulin (Ig) G responses to several antigens/pathogens were assessed by a multiplex bead assay (MBA), and the recombinant Taenia solium T24H antigen was included. Of all students tested, 8.0% were positive to rT24H, but in some schools 25–30%. A cluster of 12 widespread school locations showed not only a relative risk of 3.23 for T. solium exposure and significantly higher IgG responses (P < 0.001) but also significantly lower elevation (P = 0.04) (m, above sea level) compared with schools outside the cluster. All schools at elevations < 425 m showed significantly higher IgG responses (P = 0.017) than schools at elevations 3 425 m. The MBA is an excellent serological platform that provides cost-effective opportunities to expand testing in serosurveys.

Copyright information:

Copyright © 2018 by The American Society of Tropical Medicine and Hygiene.

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