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Author Notes:

Dr. Huaye Zhang, Department of Neuroscience and Cell Biology,Rutgers Robert Wood Johnson Medical School, 675 Hoes Lane West, Piscataway, NJ 08854. E-mail: huaye.zhang@rutgers.edu.

The authors declare no competing financial interests.

Subjects:

Research Funding:

This work was supported by National Institutes of Health Grants NS081674 and NS083378 to B.W.; AG060285 to V.F.; NS089737 and NS102780 to Q.C.; and NS089578 to H.Z.

S.M. was supported by National Institutes of Health Grant NS082619; the McCabe Fund Fellow Award; the University of Pennsylvania Alzheimer's Disease Core Center;the Intellectual and Developmental Disabilities Research Center at the Children's Hospital of Philadelphia; and the University of Pennsylvania; and the Philadelphia Foundation.

C.G.A. was supported by Maratona da Saude Award H2020/JPND (JPCOFUND/0004/2015-NAB3); and iNOVA4Health (UID/Multi/04462/2013; Fundação para a Ciência e Tecnologia/Ministério da Educação e Ciência/PT2020).

Keywords:

  • Science & Technology
  • Life Sciences & Biomedicine
  • Neurosciences
  • Neurosciences & Neurology
  • endosomes
  • membrane trafficking
  • polarity
  • neurons
  • autophagy
  • lysosome
  • AMYLOID PRECURSOR PROTEIN
  • AMYOTROPHIC-LATERAL-SCLEROSIS
  • AUTOPHAGY-LYSOSOMAL FUNCTION
  • BACE1 RETROGRADE TRANSPORT
  • PARKIN-MEDIATED MITOPHAGY
  • CHOLESTEROL SENSOR ORP1L
  • LATE ENDOSOMAL TRANSPORT
  • CENTRAL-NERVOUS-SYSTEM
  • LONG-TERM DEPRESSION
  • ALZHEIMERS-DISEASE

The Endolysosomal System and Proteostasis: From Development to Degeneration

Tools:

Journal Title:

Journal of Neuroscience Nursing

Volume:

Volume 38, Number 44

Publisher:

, Pages 9364-9374

Type of Work:

Article | Final Publisher PDF

Abstract:

How do neurons adapt their endolysosomal system to address the particular challenge of membrane transport across their elaborate cellular landscape and to maintain proteostasis for the lifetime of the organism? Here we review recent findings that address this central question. We discuss the cellular and molecular mechanisms of endolysosomal trafficking and the autophagy pathway in neurons, as well as their role in neuronal development and degeneration. These studies highlight the importance of understanding the basic cell biology of endolysosomal trafficking and autophagy and their roles in the maintenance of proteostasis within the context of neurons, which will be critical for developing effective therapies for various neurodevelopmental and neurodegenerative disorders.

Copyright information:

© 2018 The Authors.

This is an Open Access work distributed under the terms of the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/).
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