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Author Notes:

Bing Yao: bing.yao@emory.edu

JK and BY wrote the review together.

EB and ZW helped with revisions.

EB contributed to the MDD section.

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Subjects:

Keywords:

  • Science & Technology
  • Life Sciences & Biomedicine
  • Genetics & Heredity
  • epigenetics
  • neuropsychiatric disorders
  • DNA methylation
  • Rett syndrome
  • Fragile X syndrome
  • autism spectrum disorders
  • schizophrenia
  • major depressive disorders
  • MENTAL-RETARDATION PROTEIN
  • LONG NONCODING RNAS
  • CHROMATIN-REMODELING COMPLEX
  • DNA METHYLTRANSFERASES DNMT3A
  • CLUSTERED PROTOCADHERIN GENES
  • MAJOR DEPRESSIVE DISORDER
  • H3 LYSINE-27 METHYLATION
  • CELL SELF-RENEWAL
  • FRAGILE-X
  • DE-NOVO

Epigenetic Regulations in Neuropsychiatric Disorders

Tools:

Journal Title:

Frontiers in Genetics

Volume:

Volume 10

Publisher:

, Pages 268-268

Type of Work:

Article | Final Publisher PDF

Abstract:

Precise genetic and epigenetic spatiotemporal regulation of gene expression is critical for proper brain development, function and circuitry formation in the mammalian central nervous system. Neuronal differentiation processes are tightly regulated by epigenetic mechanisms including DNA methylation, histone modifications, chromatin remodelers and non-coding RNAs. Dysregulation of any of these pathways is detrimental to normal neuronal development and functions, which can result in devastating neuropsychiatric disorders, such as depression, schizophrenia and autism spectrum disorders. In this review, we focus on the current understanding of epigenetic regulations in brain development and functions, as well as their implications in neuropsychiatric disorders.

Copyright information:

© 2019 Kuehner, Bruggeman, Wen and Yao.

This is an Open Access work distributed under the terms of the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/).
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