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Author Notes:

Primary Contact: Jeffrey M. Meyers, MD, University of Rochester Medical Center, Division of Neonatology, 601 Elmwood Avenue, Box 651, Rochester NY 14642; Phone: 585-275-6197; Fax: 585-461-3614, jeff_meyers@urmc.rochester.edu.

See publication for full list of acknowledgements.

The authors have no disclosures or conflicts of interest to resolve.

Subjects:

Keywords:

  • Science & Technology
  • Life Sciences & Biomedicine
  • Obstetrics & Gynecology
  • Pediatrics
  • POSTNATAL-GROWTH
  • CHILDREN BORN
  • VLBW INFANTS
  • PRETERM
  • ASSOCIATION
  • NUTRITION
  • BRAIN
  • AGE

Neurodevelopmental outcomes among extremely premature infants with linear growth restriction

Tools:

Journal Title:

Journal of Perinatology

Volume:

Volume 39, Number 2

Publisher:

, Pages 193-202

Type of Work:

Article | Post-print: After Peer Review

Abstract:

Objective: To compare neurodevelopmental outcomes in linear growth-restricted (LGR) infants born <29 weeks with and without weight gain out of proportion to linear growth. Study design: We compared 2-year neurodevelopmental outcomes between infants with and without LGR and between LGR infants with and without weight gain out of proportion to linear growth. The outcomes were Bayley-III cognitive, motor, and language scores, cerebral palsy, Gross Motor Function Classification System (GMFCS) level ≥ 2, and neurodevelopmental impairment. Result: In total, 1227 infants were analyzed. LGR infants were smaller and less mature at birth, had higher BMI, and had lower Bayley-III language scores (82.3 vs. 85.0, p < 0.05). Among infants with LGR, infants with high BMI had lower language scores compared with those with low-to-normal BMI (80.8 vs. 83.3, p < 0.05), and were more likely to have GMFCS level ≥2 and neurodevelopmental impairment. Conclusion: Among infants with LGR, weight gain out of proportion to linear growth was associated with poorer neurodevelopmental outcomes.

Copyright information:

© 2018, Springer Nature America, Inc.

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