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Author Notes:
Craig M. Coopersmith, 101 Woodruff Circle, Suite WMB 5105, Atlanta, GA 30322. E-mail: cmcoop3@emory.edu
Authors declared no conflicts of interest.
Subject:
Research Funding:
This work was supported by the National Institutes of Health under grants GM072808, GM095442, GM104323, GM109779, and GM113228.
Keywords:
- Critical care
- gut
- intensive care unit
- intestine
- microbiome
Critical illness and the role of the microbiome.
Abstract:
The number of microbes living within the intestinal lumen is similar to the number of all cells of human origin in the host. Although historically little attention has been paid to the massive microbial community residing inside each of us, the last few years have witnessed an explosion of information related to the role of the microbiome in the maintenance of health and in the pathogenesis of disease. Here, we review data suggesting that the microbiome is converted into a pathobiome in critical illness and potential strategies for targeting the microbiome for therapeutic gain in the intensive care unit.
Copyright information:
© 2018 The Authors. Acute Medicine & Surgery published by John Wiley & Sons Australia, Ltd on behalf of Japanese Association for Acute Medicine
This is an Open Access work distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/).
