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Author Notes:

Correspondence: massimo.dominici@unimore.it

EMF contributed to the conception and design, collection and assembly of data, data analysis and interpretation, and manuscript writing.

OC, IM, AM, GG, AVS, and EV contributed to the collection and assembly of the data and data analysis and interpretation.

EMH contributed to the manuscript writing.

GB, LP, MP, and GDS provided the materials.

MD contributed to the conception and design, financial support, data analysis and interpretation, manuscript writing, and final approval of the manuscript.

All authors read and approved the final manuscript.

The authors declare that they have no competing interests.

Subjects:

Research Funding:

This work was made possible in parts by grants from the European Commission FP7/2007-2013 (grant no. 241879) REBORNE Project, from European Commission H2020 (grant no. 733288) Orthounion Project, from MIUR “Dipartimenti Eccellenti 2017”, Regione Emilia Romagna: Programma di Ricerca Regione-Università 2010–2012—Strategic Program Regenerative Medicine of Cartilage and Bone (grant no. PRUa1RI-2012-007) and Fondazione Guido Berlucchi.

Keywords:

  • Science & Technology
  • Life Sciences & Biomedicine
  • Cell Biology
  • Medicine, Research & Experimental
  • Research & Experimental Medicine
  • MSC
  • HOXB7
  • Aging
  • bFGF
  • HUMAN-BONE-MARROW
  • STEM-CELLS
  • GENE-EXPRESSION
  • STROMAL CELLS
  • TISSUE
  • DIFFERENTIATION
  • PROLIFERATION
  • CHONDROGENESIS
  • REGENERATION
  • FIBROBLASTS

Impact of HOXB7 overexpression on human adipose-derived mesenchymal progenitors

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Journal Title:

Stem Cell Research and Therapy

Volume:

Volume 10, Number 1

Publisher:

, Pages 101-101

Type of Work:

Article | Final Publisher PDF

Abstract:

Background: The ex vivo expansion potential of mesenchymal stromal/stem cells (MSC) together with their differentiation and secretion properties makes these cells an attractive tool for transplantation and tissue engineering. Although the use of MSC is currently being tested in a growing number of clinical trials, it is still desirable to identify molecular markers that may help improve their performance both in vitro and after transplantation. Methods: Recently, HOXB7 was identified as a master player driving the proliferation and differentiation of bone marrow mesenchymal progenitors. In this study, we investigated the effect of HOXB7 overexpression on the ex vivo features of adipose mesenchymal progenitors (AD-MSC). Results: HOXB7 increased AD-MSC proliferation potential, reduced senescence, and improved chondrogenesis together with a significant increase of basic fibroblast growth factor (bFGF) secretion. Conclusion: While further investigations and in vivo models shall be applied for better understanding, these data suggest that modulation of HOXB7 may be a strategy for innovative tissue regeneration applications.

Copyright information:

© 2019 The Author(s).

This is an Open Access work distributed under the terms of the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/).
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