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Author Notes:

Correspondence should be addressed to Zanthia Wiley; zwiley@emory.edu

Zanthia Wiley ORCID: https://orcid.org/0000-0002-9718-3709

The authors declare that they have no conflicts of interest.



  • Q fever
  • zoonotic disease
  • Coxiella burnetii
  • Chronic Q fever
  • endocarditis
  • vascular involvement
  • risk factors
  • vascular surgery
  • valvular defects
  • aneurysms
  • vascular prostheses
  • weight loss
  • fatigue
  • abdominal pain
  • antibody detection
  • doxycycline
  • hydroxychloroquine
  • surgery
  • mortality

Chronic Q Fever with Vascular Involvement: Progressive Abdominal Pain in a Patient with Aortic Aneurysm Repair in the United States.


Journal Title:

Case Reports in Infectious Diseases


Volume 2019


, Pages 5369707-5369707

Type of Work:

Article | Final Publisher PDF


Q fever is a zoonotic bacterial infection caused by Coxiella burnetii. Chronic Q fever comprises less than five percent of all Q fever cases and, of those, endocarditis is the most common presentation (up to 78% of cases), followed by vascular involvement. Risk factors for chronic Q fever with vascular involvement include previous vascular surgery, preexisting valvular defects, aneurysms, and vascular prostheses. The most common symptoms of chronic Q fever with vascular involvement are nonspecific, including weight loss, fatigue, and abdominal pain. Criteria for diagnosis of chronic Q fever include clinical evidence of infection and laboratory criteria (antibody detection, detection of Coxiella burnetii DNA, or growth in culture). Treatment of chronic Q fever with vascular involvement includes a prolonged course of doxycycline and hydroxychloroquine (≥18 months) as well as early surgical intervention, which has been shown to improve survival. Mortality is high in untreated chronic Q fever. We report a case of chronic Q fever with vascular involvement in a 77-year-old man with prior infrarenal aortic aneurysm repair, who lived near a livestock farm in the southeastern United States.

Copyright information:

© 2019 Zanthia Wiley et al.

This is an Open Access work distributed under the terms of the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/).
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