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Author Notes:

Correspondence: Jonathan Li, MD, MMSc, Division of Infectious Diseases, Brigham and Women’s Hospital, Harvard Medical School, 65 Landsdowne Street, Rm 421, Cambridge, MA 02139 (jli@bwh.harvard.edu)

V.C.M. has received research funding from Gilead.

B.O.T. has served as a paid consultant to ViiV, Gilead, and Janssen and on the Clinical Care Options speakers bureau and has received grant funding to his institution from ViiV/ GlaxoSmithKline (GSK).

C.B.M. has received a consulting fee from NU.

C.J.F. has received payment for service on the Clinical Care Options speakers bureau and grant funding to his institution from ViiV, Gilead, Merck, Janssen, and Pfizer.

C.A.B. has received payment for GSK board membership and Infectious Diseases Society of America board membership, speakers bureau, and travel and is an associate editor for Clinical Infectious Diseases; she has received grant funding to her institution from Gilead.

T.W. has served as a paid consultant for ViiV/GSK and has received grant funding to his institution from ViiV/GSK, Gilead, and Bristol-Myers Squibb; his spouse holds stock options at Johnson & Johnson.

S.L.K. has received grant funding to her institution from Gilead.

E.P.A. reported nonfinancial support from GSK/ViiV.

J.Z.L. has served as a paid consultant and received grant funding from Gilead and Merck.

P.E.S. has served as a paid consultant to Gilead, Abbvie, Merck, Janssen, ViiV/GSK, and Bristol-Myers Squibb and has received grant funding to his institution from Gilead and ViiV/GSK.

All other authors have nothing to disclose.

Subjects:

Research Funding:

This work was supported by an investigator-sponsored study grant from ViiV HealthCare to Northwestern University (NU).

V.C.M., C.J.F., C.A.B., T.W., S.L.K., J.C., J.Z.L., and P.E.S. have received grant funding for this study to their institutions through NU from ViiV/GSK.

V.C.M. has received funding from the Emory CFAR (P30AI050409).

Keywords:

  • Science & Technology
  • Life Sciences & Biomedicine
  • Immunology
  • Infectious Diseases

No significant changes to residual viremia after switch to dolutegravir and lamivudine in a randomized trial

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Proceedings Title:

Open Forum Infectious Diseases

Conference Name:

Infectious Diseases Society of America

Publisher:

Conference Place:

United States

Volume/Issue:

Volume 21 | Issue 3

Publication Date:

Type of Work:

Conference | Final Publisher PDF

Abstract:

In the ASPIRE trial, antiretroviral therapy (ART) switch to dolutegravir plus lamivudine (DTG+3TC) was comparable to 3-drug ART in maintaining viral suppression by standard viral load assays. We used an ultrasensitive assay to assess whether this switch led to increased residual viremia. At entry, levels of residual viremia did not differ significantly between arms (DTG+3TC vs 3-drug ART: mean, 5.0 vs 4.2 HIV-1 RNA copies/mL; P = .64). After randomization, no significant between-group differences were found at either week 24 or 48. These results show no evidence for increased viral replication on DTG+3TC and support its further investigation as a dual ART strategy.

Copyright information:

© The Author(s) 2019. Published by Oxford University Press on behalf of Infectious Diseases Society of America.

This is an Open Access work distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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