About this item:

263 Views | 74 Downloads

Author Notes:

Address for correspondence: Philip J. Peters, Centers for Disease Control and Prevention, 1600 Clifton Rd NE, Mailstop E45, Atlanta, GA 30333, USA; email: pjpeters@cdc.gov

Subjects:

Research Funding:

This publication was made possible by support from the Division of HIV/AIDS Prevention and the Division of Healthcare Quality Promotion, CDC.

Keywords:

  • Science & Technology
  • Life Sciences & Biomedicine
  • Immunology
  • Infectious Diseases
  • NASAL CARRIAGE
  • UNITED-STATES
  • SKIN INFECTIONS
  • PREVALENCE
  • EMERGENCE
  • POPULATION
  • CARE
  • MRSA
  • SEX
  • MEN

Methicillin-Resistant Staphylococcus aureus Colonization of the Groin and Risk for Clinical Infection among HIV-infected Adults

Show all authors Show less authors

Tools:

Journal Title:

Emerging Infectious Disease

Volume:

Volume 19, Number 4

Publisher:

, Pages 623-629

Type of Work:

Article | Final Publisher PDF

Abstract:

Data on the interaction between methicillin-resistant Staphylococcus aureus (MRSA) colonization and clinical infection are limited. During 2007-2008, we enrolled HIVinfected adults in Atlanta, Georgia, USA, in a prospective cohort study. Nares and groin swab specimens were cultured for S. aureus at enrollment and after 6 and 12 months. MRSA colonization was detected in 13%-15% of HIV-infected participants (n = 600, 98% male) at baseline, 6 months, and 12 months. MRSA colonization was detected in the nares only (41%), groin only (21%), and at both sites (38%). Over a median of 2.1 years of follow-up, 29 MRSA clinical infections occurred in 25 participants. In multivariate analysis, MRSA clinical infection was significantly associated with MRSA colonization of the groin (adjusted risk ratio 4.8) and a history of MRSA infection (adjusted risk ratio 3.1). MRSA prevention strategies that can effectively prevent or eliminate groin colonization are likely necessary to reduce clinical infections in this population.

Copyright information:

Not subject to copyright

This is an Open Access work distributed under the terms of the Creative Commons Universal : Public Domain Dedication License (http://creativecommons.org/publicdomain/zero/1.0/).

Creative Commons License

Export to EndNote