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Author Notes:

Corresponding Author: Hyunsuk Shim, PhD Department of Radiology and Imaging Sciences, Emory University, Atlanta, GA, USA; E-mail: hshim@emory.edu

We would like to thank the following people for their assistance in collecting and analyzing data: Dr. Peter Barker, Dr. Michal Povazan, Dr. Sarah Dupont, Mr. Michael Larche, Mr. Robert Smith, Ms. Samira Yeboah, and Ms. Sarah Basadre.

The authors have no conflict of interest to declare.


Research Funding:

This work is funded by NIH grants U01CA172027, R01CA214557, U01EB028145, and F30CA206291.


  • cloud platform
  • radiation therapy
  • spectroscopic MRI

The Brain Imaging Collaboration Suite (BrICS): A Cloud Platform for Integrating Whole-Brain Spectroscopic MRI into the Radiation Therapy Planning Workflow.


Journal Title:

Tomography : a journal for imaging research


Volume 5, Number 1


, Pages 184-191

Type of Work:

Article | Final Publisher PDF


Glioblastoma has poor prognosis with inevitable local recurrence despite aggressive treatment with surgery and chemoradiation. Radiation therapy (RT) is typically guided by contrast-enhanced T1-weighted magnetic resonance imaging (MRI) for defining the high-dose target and T2-weighted fluid-attenuation inversion recovery MRI for defining the moderate-dose target. There is an urgent need for improved imaging methods to better delineate tumors for focal RT. Spectroscopic MRI (sMRI) is a quantitative imaging technique that enables whole-brain analysis of endogenous metabolite levels, such as the ratio of choline-to-N-acetylaspartate. Previous work has shown that choline-to-N-acetylaspartate ratio accurately identifies tissue with high tumor burden beyond what is seen on standard imaging and can predict regions of metabolic abnormality that are at high risk for recurrence. To facilitate efficient clinical implementation of sMRI for RT planning, we developed the Brain Imaging Collaboration Suite (BrICS; https://brainimaging.emory.edu/brics-demo), a cloud platform that integrates sMRI with standard imaging and enables team members from multiple departments and institutions to work together in delineating RT targets. BrICS is being used in a multisite pilot study to assess feasibility and safety of dose-escalated RT based on metabolic abnormalities in patients with glioblastoma (Clinicaltrials.gov NCT03137888). The workflow of analyzing sMRI volumes and preparing RT plans is described. The pipeline achieved rapid turnaround time by enabling team members to perform their delegated tasks independently in BrICS when their clinical schedules allowed. To date, 18 patients have been treated using targets created in BrICS and no severe toxicities have been observed.

Copyright information:

© 2019 The Authors

This is an Open Access work distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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