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Author Notes:

Send correspondence to Sarah K. Wise, MD, MSCR, Emory University, Department of Otolaryngology–Head and Neck Surgery, 550 Peachtree Street, MOT 11 Floor, Atlanta, GA 30308. Email: skmille@emory.edu

Conflicts of Interest: DelGaudi—Spirox (research support) and IntersectENT (stock); Wise—OptiNose (scientific advisory board) and SinopSys Surgical (scientific advisory board).



  • Allergy
  • atopy
  • chronic rhinosinusitis
  • nasal polyposis
  • sinusitis

The relationship between allergy and chronic rhinosinusitis.


Journal Title:

Laryngoscope Investigative Otolaryngology


Volume 4, Number 1


, Pages 13-17

Type of Work:

Article | Final Publisher PDF


Objective: To summarize the current evidence regarding a relationship between chronic rhinosinusitis (CRS) and allergy. Methods: Literature review. Results: Despite frequent assumption of an association between CRS and allergy the relationship between these entities remains poorly defined. Certain CRS entities, however, have demonstrated a strong association with allergy-namely allergic fungal rhinosinusitis and central compartment atopic disease. Conclusion: Studies are heterogeneous and largely retrospective in design with inconclusive evidence for an association between CRS and allergy. Knowledge of CRS endotypes is important in order to understand which entities may or may not be associated with allergy. Level of Evidence: 5.

Copyright information:

© 2018 The Authors. Laryngoscope Investigative Otolaryngology published by Wiley Periodicals, Inc. on behalf of The Triological Society.

This is an Open Access work distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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