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Author Notes:

Corresponding Author: Arif N. Ali, MD, 1365 Clifton Rd NE, Atlanta, GA 30322, Phone: 404-778-3658, aali24@emory.edu.

Dr. Movsas reports research grants from Varian, Inc. and Philips, Inc.

Drs. Chen and Penas-Prado report grants from NCI.

Dr. Jones reports receiving speaker fees from Lilly.

Dr. Yung reports research grant to his institution from RTOG and fees for serving on scientific advisory board of DNAtrix.


Research Funding:

This study was supported by grants U10CA21661 (RTOG-Ops-Stat), U10CA180868 (NRG Oncology Operations), U10CA180822 (NRG Oncology SDMC), U10CA37422 (CCOP), from the National Cancer Institute (NCI).


  • Science & Technology
  • Life Sciences & Biomedicine
  • Oncology
  • Clinical Neurology
  • Neurosciences & Neurology
  • GBM
  • Glioma
  • Hyperfractionated
  • Astrocytoma
  • Oligodendroglioma

NRG oncology RTOG 9006: a phase III randomized trial of hyperfractionated radiotherapy (RT) and BCNU versus standard RT and BCNU for malignant glioma patients

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Journal Title:

Journal of Neuro-Oncology


Volume 137, Number 1


, Pages 39-47

Type of Work:

Article | Post-print: After Peer Review


From 1990 to 1994, patients with newly diagnosed malignant gliomas were enrolled and randomized between hyperfractionated radiation (HFX) of 72.0 Gy in 60 fractions given twice daily and 60.0 Gy in 30 fractions given once daily. All patients received 80 mg/m 2 of 1,3 bis(2 chloroethyl)-1 nitrosourea on days 1–3 q8 weeks for 1 year. Patients were stratified by age, KPS, and histology. The primary endpoint was overall survival (OS), with secondary endpoints including progression-free survival (PFS) and toxicity. Out of the 712 patients accrued, 694 (97.5%) were analyzable cases (350 HFX, 344 standard arm). There was no significant difference between the arms on overall acute or late treatment-related toxicity. No statistically significant effect for HFX, as compared to standard therapy, was found on either OS, with a median survival time (MST) of 11.3 versus 13.1 months (p = 0.20) or PFS, with a median PFS time of 5.7 versus 6.9 months (p = 0.18). The treatment effect on OS remained insignificant based on the multivariate analysis (hazard ratio 1.16; p = 0.0682). When OS was analyzed by histology subgroup there was also no significant difference between the two arms for patients with glioblastoma multiforme (MST: 10.3 vs. 11.2 months; p = 0.34), anaplastic astrocytoma (MST: 69.8 vs. 50.0 months; p = 0.91) or anaplastic oligodendroglioma (MST: 92.1 vs. 66.5 months; p = 0.33). Though this trial provided many invaluable secondary analyses, there was no trend or indication of a benefit to HFX radiation to 72.0 Gy in any subset of malignant glioma patients.

Copyright information:

© 2018, Springer Science+Business Media, LLC.

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