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Author Notes:

Correspondence and requests for materials should be addressed to K.C.B. (email: kathleen.barnes@ucdenver.edu).

See publication for full list of authors.

These authors contributed equally: Rasika A. Mathias, Kathleen C. Barnes.

M.D., N.R., and T.M.B, analysed the data, interpreted the data, and wrote the paper.

S.C., A.M.L., A.S., M.P.B., G.W., H.R.J. and G.B. analysed and interpreted the data.

M.C. performed genotyping.

K.C.B., R.A.M., T.H.B. and M.A.T. conceived the experiments, interpreted the data, and wrote the paper.

C.V., C.R.G., V.E.O., A.D., D.G.T., N.A., M.I.A., P.C.A., E.B., C.B., L.C., A.C., G.M.D., C.E., M.U.F., T.S.F., C.F., J.G.F., W.G., P.A.G., N.N.H., R.D.H., E.F.H., S.J., E.E.K., J.K., R.K., L.A.L., E.M.L., A.L., P.M., T.M., A.M., D.M., D.L.N., T.D.O., R.R.O., C.O.O., O.O., Z.S.Q., C.R., N.V., H.W., R.J.W., J.G.W., S.S., C.O., E.G.B., L.K.W. and I.R. contributed to interpretation of results and critically reviewed the manuscript.

CAAPA provided infrastructure, biospecimens and associated phenotype data, and intellectual input for the overall design and execution of the study.

We thank Goncalo Abecasis for coordinating inclusion of the CAAPA reference panel on the Michigan Imputation Server, Todd Deppe, Estelle Giraud, Cindy Lawley from Illumina for genotyping services, and Pat Oldewurtel for administrative and technical support.

All authors declare no competing interests.

Subjects:

Keywords:

  • Science & Technology
  • Multidisciplinary Sciences
  • Science & Technology - Other Topics
  • GENOME-WIDE ASSOCIATION
  • TOTAL SERUM IGE
  • LUNG-FUNCTION
  • GENE
  • LINKAGE
  • METAANALYSIS
  • CHILDREN
  • DIVERSE
  • STAT6
  • ATHEROSCLEROSIS

Association study in African-admixed populations across the Americas recapitulates asthma risk loci in non-African populations

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Journal Title:

Nature Communications

Volume:

Volume 10, Number 1

Publisher:

, Pages 880-880

Type of Work:

Article | Final Publisher PDF

Abstract:

Asthma is a complex disease with striking disparities across racial and ethnic groups. Despite its relatively high burden, representation of individuals of African ancestry in asthma genome-wide association studies (GWAS) has been inadequate, and true associations in these underrepresented minority groups have been inconclusive. We report the results of a genome-wide meta-analysis from the Consortium on Asthma among African Ancestry Populations (CAAPA; 7009 asthma cases, 7645 controls). We find strong evidence for association at four previously reported asthma loci whose discovery was driven largely by non-African populations, including the chromosome 17q12–q21 locus and the chr12q13 region, a novel (and not previously replicated) asthma locus recently identified by the Trans-National Asthma Genetic Consortium (TAGC). An additional seven loci reported by TAGC show marginal evidence for association in CAAPA. We also identify two novel loci (8p23 and 8q24) that may be specific to asthma risk in African ancestry populations.

Copyright information:

© 2019, The Author(s).

This is an Open Access work distributed under the terms of the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/).
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