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Author Notes:

Correspondence: rjones5@emory.edu

R.M.J. and T.M.D. conceived and designed the experiments.

L.L. and C.R.N. performed experiments on the Drosophila animal model, and T.M.D., B.J.S., B.S.R., and J.A.O. performed experiments on the murine animal model.

R.M.J. and T.M.D. wrote the manuscript.

The authors declare no competing interests.


Research Funding:

This research was funded by the National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases to R.M.J. (DK098391), and the Emory University Integrated Cellular Imaging Microscopy Core.

T.M.D. was supported by a Crohn's and Colitis Foundation, United States (CCFA) Research Fellowship Award grant.

B.S.R. was supported by a Research Training in Translational Gastroenterology and Hepatology training grant (T32DK108735).

B.J.S. was supported by an NIH Research Training Grant (F30DK117570).


  • Biological Sciences
  • Cell Biology
  • Microbiology

Lactococcus Lactis Subsp. cremoris Is an Efficacious Beneficial Bacterium that Limits Tissue Injury in the Intestine.


Journal Title:



Volume 12


, Pages 356-367

Type of Work:

Article | Final Publisher PDF


The use of beneficial bacteria to promote health is widely practiced. However, experimental evidence corroborating the efficacy of bacteria promoted with such claims remains limited. We address this gap by identifying a beneficial bacterium that protects against tissue damage and injury-induced inflammation in the gut. We first employed the Drosophila animal model to screen for the capacity of candidate beneficial bacteria to protect the fly gut against injury. From this screen, we identified Lactococcus lactis subsp. cremoris as a bacterium that elicited potent cytoprotective activity. Then, in a murine model, we demonstrated that the same strain confers powerful cytoprotective influences against radiological damage, as well as anti-inflammatory activity in a gut colitis model. In summary, we demonstrate the positive salutary effects of a beneficial bacterium, namely, L. lactis subsp. cremoris on intestinal tissue and propose the use of this strain as a therapeutic to promote intestinal health.

Copyright information:

© 2019 The Author(s)

This is an Open Access work distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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