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Author Notes:

Addresses for correspondence: Akhil Maheshwari, MD, 5 Tampa General Cir, Suite HMT 450.19, Tampa, FL 33606-3601, Ph: (813) 844-3437; Fax: (813) 844-1671; akhilm@health.usf.edu.

The authors disclose no conflicts.

Subject:

Research Funding:

National Institutes of Health award HL124078 (A.M.) and HL128942 (R.P.)

Keywords:

  • Science & Technology
  • Life Sciences & Biomedicine
  • Pediatrics
  • Surgery
  • NEC
  • Anemia
  • Transfusion
  • RBC
  • Intestinal injury
  • BIRTH-WEIGHT INFANTS
  • PREMATURE-INFANTS
  • PRETERM INFANTS
  • TISSUE OXYGENATION
  • ASSOCIATION
  • RISK
  • INCREASE
  • ACTIVATION
  • MECHANISM
  • INJURY

Anemia, red blood cell transfusions, and necrotizing enterocolitis

Tools:

Journal Title:

Seminars in Pediatric Surgery

Volume:

Volume 27, Number 1

Publisher:

, Pages 47-51

Type of Work:

Article | Post-print: After Peer Review

Abstract:

In the past 15 years, multiple clinical studies have identified a temporal association between red blood cell (RBC) transfusions and necrotizing enterocolitis (NEC). With some variability, most of these studies indicate that up to one-third of all cases of NEC involving very low-birth weight infants may occur within 24–48 h after receiving a RBC transfusion. There is also evidence that the risk of such transfusion-associated NEC may be higher in infants transfused with the greatest severity of anemia. In this article, we summarize the clinical evidence pertaining to these issues; specifically, the contribution of RBC transfusions, and the contribution of severity of underlying anemia, to the pathogenesis of a type of NEC potentially termed, “transfusion/anemia-associated NEC.”

Copyright information:

© 2018 Elsevier Inc.

This is an Open Access work distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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