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Author Notes:

Ravi Mangal Patel, MD, MSc, 2015 Uppergate Dr. NE, 3rd floor, Division of Neonatology, Emory University School of Medicine, Atlanta, GA 30322. rmpatel@emory.edu; Tel: (404) 727-5905; Fax: (404) 727-3236.

Ravi Patel received honorarium and travel support from Mednax, Inc.

Mark Underwood received honorarium and travel support from Abbott and is on the scientific advisory board for Avexegen.

The authors are not endorsing the use of any specific probiotic product.

Subject:

Research Funding:

Ravi Patel was supported by NIH awards KL2 TR000455, UL1 TR000454 & K23 HL128942.

Mark Underwood was supported by NIH award R01 HD059127.

Keywords:

  • Science & Technology
  • Life Sciences & Biomedicine
  • Pediatrics
  • Surgery
  • Preterm
  • Neonate
  • Bacteria
  • Microbiome
  • Gut
  • Meta-analysis
  • BIRTH-WEIGHT INFANTS
  • EMPIRICAL ANTIBIOTIC-TREATMENT
  • LATE-ONSET SEPSIS
  • PRETERM INFANTS
  • BIFIDOBACTERIUM-BREVE
  • PROPHYLACTIC PROBIOTICS
  • LACTOBACILLUS-REUTERI
  • PREVENTION
  • MILK
  • PATHOGENESIS

Probiotics and necrotizing enterocolitis

Tools:

Journal Title:

Seminars in Pediatric Surgery

Volume:

Volume 27, Number 1

Publisher:

, Pages 39-46

Type of Work:

Article | Post-print: After Peer Review

Abstract:

In this review, we summarize existing knowledge regarding the effects of probiotics on necrotizing enterocolitis (NEC). We review the role of the microbiome in NEC and pre-clinical data on mechanisms of probiotic action. Next, we summarize existing randomized controlled trials and observational studies of probiotics to prevent NEC. We also summarize findings from several recent meta-analyses and report a new cumulative meta-analysis of probiotic trials. Finally, we review data from cohorts routinely using commercially available probiotics. Our goal is to inform clinicians about the risks and benefits of probiotics, which may be helpful for those considering use in preterm infants to prevent NEC, death, or sepsis.

Copyright information:

© 2018 Elsevier Inc.

This is an Open Access work distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (http://creativecommons.org/licenses/by-nc-nd/4.0/).

Creative Commons License

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