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Author Notes:

Reprint requests: Bulent Okan Yildiz, M.D., Hacettepe University School of Medicine, Department of Internal Medicine, Division of Endocrinology and Metabolism, Hacettepe, Ankara 06100, Turkey yildizbo@yahoo.com.

Subjects:

Keywords:

  • Science & Technology
  • Life Sciences & Biomedicine
  • Obstetrics & Gynecology
  • Reproductive Biology
  • Dyslipidemia
  • first-degree relatives
  • hypertension
  • metabolic syndrome
  • polycystic ovary syndrome
  • IMPAIRED GLUCOSE-TOLERANCE
  • FIRST-DEGREE RELATIVES
  • II DIABETES-MELLITUS
  • 1ST DEGREE RELATIVES
  • INSULIN-RESISTANCE
  • 1ST-DEGREE RELATIVES
  • CARDIOVASCULAR RISK
  • FAMILY-HISTORY
  • SYNDROME PCOS
  • DEHYDROEPIANDROSTERONE-SULFATE

Metabolic syndrome, hypertension, and hyperlipidemia in mothers, fathers, sisters, and brothers of women with polycystic ovary syndrome: a systematic review and meta-analysis

Tools:

Journal Title:

Fertility and Sterility

Volume:

Volume 109, Number 2

Publisher:

, Pages 356-+

Type of Work:

Article | Post-print: After Peer Review

Abstract:

Objective: To provide an evidence-based assessment of metabolic syndrome, hypertension, and hyperlipidemia in first-degree relatives of women with polycystic ovary syndrome (PCOS). Design: Systematic review and meta-analysis. Setting: Not applicable. Patient(s): Mothers, fathers, sisters, and brothers of women with and without PCOS. Intervention(s): An electronic-based search with the use of PubMed from 1960 to June 2015 and cross-checked references of relevant articles. Main Outcome Measure(s): Metabolic syndrome, hypertension and dyslipidemia, and surrogate markers, including systolic blood pressure (BP), diastolic BP, total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, and triglycerides. Result(s): Fourteen of 3,346 studies were included in the meta-analysis. Prevalence of the following was significantly increased in relatives of women with PCOS: metabolic syndrome (risk ratio [RR] 1.78 [95% confidence interval 1.37, 2.30] in mothers, 1.43 [1.12, 1.81] in fathers, and 1.50 [1.12, 2.00] in sisters), hypertension (RR 1.93 [1.58, 2.35] in fathers, 2.92 [1.92, 4.45] in sisters), and dyslipidemia (RR 3.86 [2.54, 5.85] in brothers and 1.29 [1.11, 1.50] in fathers). Moreover, systolic BP (mothers, sisters, and brothers), total cholesterol (mothers and sisters), low-density lipoprotein cholesterol (sisters), and triglycerides (mothers and sisters) were significantly higher in first-degree relatives of PCOS probands than in controls. Conclusion(s): Our results show evidence of clustering for metabolic syndrome, hypertension, and dyslipidemia in mothers, fathers, sisters, and brothers of women with PCOS. Systematic Review Registration Number: PROSPERO 2016 CRD42016048557.

Copyright information:

© 2017 American Society for Reproductive Medicine

This is an Open Access work distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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