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Author Notes:

Email: jeb.jones@emory.edu

I have read the journal’s policy and the authors of this manuscript have the following competing interests: PSS reports research funding from NIH, research grants and personal fees from Centers for Disease Control and Prevention, research fees from Gilead Sciences, and research fees from MAC AIDS Fund.


Research Funding:

An earlier version of this paper was commissioned by UNAIDS for a meeting convened in October 2017.

JJ received compensation for producing the earlier version of the paper. UNAIDS reviewed and provided feedback on earlier drafts of the paper; however, final editorial decisions were made by coauthors.


  • Science & Technology
  • Life Sciences & Biomedicine
  • Medicine, General & Internal
  • General & Internal Medicine
  • MEN

Progress in the HIV epidemic: Identifying goals and measuring success


Journal Title:

PLoS Medicine


Volume 16, Number 1


, Pages e1002729-e1002729

Type of Work:

Article | Final Publisher PDF


Substantial progress has been made towards the goal of ending the HIV/AIDS epidemic due to advancements in both prevention and treatment of HIV. However, major challenges still remain. We describe basic principles of epidemic control in the context of HIV and identify a number of attainable goals in terms of control and elimination of HIV in specific populations and risk groups, given currently available HIV prevention and treatment methods. Currently available HIV prevention methods make it a feasible goal to eliminate HIV transmission attributable to mother-to-child transmission and blood transfusions. Reductions in transmission attributable to sexual behavior and injection drug use are feasible, but elimination of these modes of transmission will require further advancements in behavioral and biomedical HIV prevention. With regard to HIV-related mortality, we argue that elimination of death due to HIV-related causes is a feasible goal. HIV-related deaths should be treated as sentinel events triggering epidemiological investigation into the breakdowns in the HIV care continuum that led to them. We briefly discuss additional considerations that will affect the success of HIV prevention programs.

Copyright information:

© 2019 Jones et al.

This is an Open Access work distributed under the terms of the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/).
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