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Author Notes:

Correspondence to: Dr. Jocelyne Bachevalier, 954 Gatewood Rd NE, Atlanta, GA 30329, USA, Telephone: 404-727-9765, Fax: 404-727-8088, jbachev@emory.edu, Dr. Xiaodong Zhang, 954 Gatewood Rd NE, Atlanta, GA 30329, USA, Telephone: 1-404-712-9874, Fax:1-404-712-9917, xzhang8@emory.edu.

The authors are grateful to Ruth Connelly and Doty Kempf (DVM) at Yerkes Imaging Center for animal handling, Sudeep Patel and Dr. Chunxia Li for MRI data acquisition.

Subjects:

Research Funding:

This project was funded by NIH/NIMH grant MH0588446 (JB), the National Center for Research Resources P51RR000165, currently supported by the Office of Research Infrastructure Programs / OD P51OD011132.

Keywords:

  • Science & Technology
  • Social Sciences
  • Life Sciences & Biomedicine
  • Behavioral Sciences
  • Neurosciences
  • Psychology
  • Psychology, Multidisciplinary
  • Neurosciences & Neurology
  • Resting state fMRI
  • Functional connectivity
  • Rhesus monkey
  • INFERIOR TEMPORAL CORTEX
  • LATERAL FRONTAL-CORTEX
  • RHESUS MACAQUES
  • INFEROTEMPORAL CORTEX
  • UNCINATE FASCICLE
  • CINGULATE CORTEX
  • NEURAL SYSTEM
  • MONKEY BRAIN
  • MOTOR AREAS
  • SCHIZOPHRENIA

Decreased functional connectivity in dorsolateral prefrontal cortical networks in adult macaques with neonatal hippocampal lesions: Relations to visual working memory deficits

Tools:

Journal Title:

Neurobiology of Learning and Memory

Volume:

Volume 134

Publisher:

, Pages 31-37

Type of Work:

Article | Post-print: After Peer Review

Abstract:

Neonatal hippocampal lesions in monkeys impairs normal performance on both relational and working memory tasks, suggesting that the early lesions have impacted the normal development of prefrontal–hippocampal functional interactions necessary for normal performance on these tasks. Given that working memory processes engage distributed neuronal networks associated with the prefrontal cortex, it is critical to explore the integrity of distributed neural networks of dorsolateral prefrontal cortex (dlPFC) following neonatal hippocampal lesions in monkeys. We used resting-state functional MRI to assess functional connectivity of dlPFC networks in monkeys with neonatal neurotoxic hippocampal lesion (Neo-Hibo, n = 4) and sham-operated control animals (Neo-C, n = 4). Significant differences in the patterns of dlPFC functional networks were found between Groups Neo-Hibo and Neo-C. The within-group maps and the between-group comparisons yielded a highly coherent picture showing altered interactions of core regions of the working memory network (medial prefrontal cortex and posterior parietal cortex) as well as the dorsal (fundus of superior temporal area and superior temporal cortex) and ventral (V4 and infero-temporal cortex) visual processing areas in animals with Neo-Hibo lesions. Correlations between functional connectivity changes and working memory impairment in the same animals were found only between the dlPFC and visual cortical areas (V4 and infero-temporal cortex). Thus, the impact of the neonatal hippocampal lesions extends to multiple cortical areas interconnected with the dlPFC.

Copyright information:

© 2016

This is an Open Access work distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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