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Correspondence: elena.gomez@csic.es
EG-D and VGC conceived the study.
EG-D, RSY, TL and VGC designed the experiments.
EG-D performed laboratory experiments.
EG-D, RSY and TL performed the field experiments.
JLR and EG-D performed data analysis.
RSY, TL and JBO provided infrastructure and organized gametocyte carrier recruitment in Burkina Faso.
EG-D, JLR and VGC wrote the manuscript. TL commented on the manuscript.
All authors read and approved the final manuscript.
We would like to thank all children and their parents who participated in this study, as well as the local authorities in Burkina Faso for their support.
We are very grateful to B. Yameogo, S. Tamboula, R. Hien, J. Bazié., B. Dabiré., F. Da, A. Diasso and F. Yao in Burkina Faso for technical assistance.
We thank The Genomic Services Lab at the HudsonAlpha Institute for Biotechnology, specially Braden Boone, Angela Jones and Terri Pointer, for their help in preparing RNA-seq libraries and performing Illumina sequencing of RNA-seq and ChIP-seq samples.
The authors declare that they have not competing interests.
This work was supported by the Spanish Ministry of Economy and Competitiveness Grant BFU2015-65000-R to EG-D; Severo Ochoa Fellowship BES-2016-076276 to JLR; Spanish Ministry of Economy and Competitiveness Ramon y Cajal Grant to EG-D; French ANR grant 11-PDOC-006-01 to TL and PATH Malaria Vaccine Initiative to TL, JBO and RSY, and by U.S. Public Health Service Award R01GM035463 from the National Institutes of Health to VGC.
The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
© 2019 The Author(s).