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Author Notes:

Corresponding Author: Kenkichi Baba, 720 Westview Dr. SW. Atlanta, GA 30310; Phone: (404) 756-8978; bkenkichi@msm.edu.

Subjects:

Research Funding:

Research in the author’s laboratories is supported by NIH grants GM116760 to KB, EY018640 to CR, R01EY004864 and P30EY006360 to PMI, EY022216, EY026291 to GT, and an unrestricted departmental grant from Research to Prevent Blindness (Emory Department of Ophthalmology).

Keywords:

  • Science & Technology
  • Life Sciences & Biomedicine
  • Cell Biology
  • Medicine, Research & Experimental
  • Ophthalmology
  • Research & Experimental Medicine
  • Circadian rhythm
  • Clock genes
  • Retinal degeneration
  • Photoreceptors
  • Cell viability
  • Cone
  • Aging
  • Oscillation
  • Knockout mice
  • MAMMALIAN RETINA
  • COMPONENT
  • RHYTHM

The Retinal Circadian Clock and Photoreceptor Viability

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Journal Title:

Advances in Experimental Medicine and Biology

Volume:

Volume 1074

Publisher:

, Pages 345-350

Type of Work:

Article | Post-print: After Peer Review

Abstract:

Circadian rhythms are present in most living organisms, and these rhythms are not just a consequence of the day/night fluctuation, but rather they are generated by endogenous biological clocks with a periodicity of about 24 h. In mammals, the master pacemaker of circadian rhythms is localized in the suprachiasmatic nuclei (SCN) of the hypothalamus. The SCN controls circadian rhythms in peripheral organs. The retina also contains circadian clocks which regulate many aspects of retinal physiology, independently of the SCN. Emerging experimental evidence indicates that the retinal circadian clocks also affect ocular health, and a few studies have now demonstrated that disruption of retinal clocks may contribute to the development of retinal diseases. Our study indicates that in mice lacking the clock gene Bmal1, photoreceptor viability during aging is significantly reduced. Bmal1 knockout mice at 8–9 months of age have 20–30% less nuclei in the outer nuclear layer. No differences were observed in the other retinal layers. Our study suggests that the retinal circadian clock is an important modulator of photoreceptor health.

Copyright information:

© 2018, Springer International Publishing AG, part of Springer Nature.

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