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Author Notes:

Correspondence: Christopher N. LaRock, clarock@ucsd.edu; Victor Nizet, vnizet@ucsd.edu

Conflict of Interest Statement: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Subjects:

Research Funding:

Streptococcal research in the Nizet lab is supported by NIH grants AI077780 and AI096837. CL received fellowship support from the A.P. Giannini foundation.

Keywords:

  • Science & Technology
  • Life Sciences & Biomedicine
  • Immunology
  • inflammasome
  • caspase-1
  • IL-1 beta
  • pyroptosis
  • Streptococcus
  • GROUP-A-STREPTOCOCCUS
  • GROUP-B STREPTOCOCCUS
  • TOLL-LIKE RECEPTOR-4
  • EXPERIMENTAL PNEUMOCOCCAL MENINGITIS
  • PYOGENIC BACTERIAL-INFECTIONS
  • IMPAIRED HOST-DEFENSE
  • BLOOD-BRAIN-BARRIER
  • NLRP3 INFLAMMASOME
  • STREPTOLYSIN-O
  • CASPASE-1 ACTIVATION

Inflammasome/IL-1 beta responses to streptococcal pathogens

Tools:

Journal Title:

Frontiers in Immunology

Volume:

Volume 6, Number OCT

Publisher:

, Pages 518-518

Type of Work:

Article | Final Publisher PDF

Abstract:

Inflammation mediated by the inflammasome and the cytokine IL-1β are some of the earliest and most important alarms to infection. These pathways are responsive to the virulence factors that pathogens use to subvert immune processes, and thus are typically activated only by microbes with potential to cause severe disease. Among the most serious human infections are those caused by the pathogenic streptococci, in part because these species numerous strategies for immune evasion. Since the virulence factor armament of each pathogen is unique, the role of IL-1β and the pathways leading to its activation varies for each infection. This review summarizes the role of IL-1β during infections caused by streptococcal pathogens, with emphasis on emergent mechanisms and concepts countering paradigms determined for other organisms.

Copyright information:

© 2015 LaRock and Nizet.

This is an Open Access work distributed under the terms of the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/).
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