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To whom correspondence may be addressed. E-mail: eortlun@emory.edu, richard.johnson@ucdenver.edu, or eric.gaucher@biology.gatech.edu.
Author contributions: J.T.K., M.A.L., M.N.M., E.A.O., R.J.J., and E.A.G. designed research; J.T.K., M.A.L., M.N.M., C.C., C.L.G., and E.A.G. performed research; J.T.K., M.A.L., M.N.M., P.A.T., E.A.O., R.J.J., and E.A.G. analyzed data; and J.T.K., M.A.L., E.A.O., R.J.J., and E.A.G. wrote the paper.
Acknowledgments We thank Betül Kaçar, Valery Adorno-Cruz, and Laura O’Farrell for their assistance. This work was supported by Technological Innovation: Generating Economic Results (TI:GER), Graduate Assistance in Areas of National Need (GAANN), and Translational Research Institute for Biomedical Engineering and Science (TRIBES) programs at the Georgia Institute of Technology (J.T.K.), the Georgia Research Alliance (E.A.G.), and start-up funds from the Georgia Institute of Technology (E.A.G.), University of Colorado (R.J.J.), and Emory University (E.A.O.). Use of the Advanced Photon Source was supported by the US Department of Energy, Office of Science, Office of Basic Energy Sciences, under Contract W-31-109-Eng-38.
Conflict of interest statement: E.A.G. declares financial interest because a patent related to this research has been filed by the Georgia Institute of Technology, and this technology is licensed to General Genomics, LLC, which is a start-up founded by E.A.G.. R.J.J. is an inventor on several patents and patent applications related to lowering uric acid as a means for treating hypertension, diabetic nephropathy, and renal disease, and is a founder of XORT, Inc., which is a start-up company that has licensed these applications.
This work was supported by Technological Innovation: Generating Economic Results (TI:GER), Graduate Assistance in Areas of National Need (GAANN), and Translational Research Institute for Biomedical Engineering and Science (TRIBES) programs at the Georgia Institute of Technology (J.T.K.), the Georgia Research Alliance (E.A.G.), and start-up funds from the Georgia Institute of Technology (E.A.G.), University of Colorado (R.J.J.), and Emory University (E.A.O.).
© 2014 National Academy of Sciences.