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Author Notes:

Corresponding author: Mike Bancks, Northwestern University Feinberg School of Medicine, Department of Preventive Medicine, 680 N Lake Shore Drive, Suite 1400, Chicago, IL, 60611., michael.bancks@northwestern.edu, Telephone: + 1-312-503-4177; Fax: + 1-312-908-9588.

M.P.B. is the guarantor of this work, had full access to the data in this analysis, and takes responsibility for the integrity of the data and the accuracy of the data analysis.

All authors had access to the data and participated in creating, editing, and reviewing this manuscript.

M.P.B. researched data and wrote manuscript.

A.A. contributed to discussion and reviewed/edited manuscript. RG. reviewed/edited manuscript.

T.M. contributed discussion and reviewed/edited manuscript.

E.S. contributed to discussion and reviewed/edited manuscript.

J.S.P. contributed to discussion and reviewed/edited manuscript.

The authors thank the other investigators, the staff, and the participants of the ARIC study for their valuable contributions.

The authors report no conflicts of interest.


Research Funding:

M.P.B. was supported by the National Heart, Lung, and Blood Institute (NHLBI) of the National Institutes of Health under Award Numbers T32HL007779 and T32HL069771 to conduct the current work. ARIC is supported by NHLBI contracts HHSN268201100005C, HHSN268201100006C, HHSN268201100007C, HHSN268201100008C, HHSN268201100009C, HHSN268201100010C, HHSN268201100011C, and HHSN268201100012C. Neurocognitive data is collected by U01 2U01HL096812, 2U01HL096814, 2U01HL096899, 2U01HL096902, 2U01HL096917 from the NIH (NHLBI, NINDS, NIA and NIDCD), and with previous brain MRI examinations funded by R01-HL70825 from the NHLBI. Dr. Selvin was supported by NIH/ NIDDK grants K24DK106414 and 2R01DK089174.


  • Science & Technology
  • Life Sciences & Biomedicine
  • Clinical Neurology
  • Neurosciences & Neurology
  • Cognitive function
  • Brain magnetic resonance imaging
  • Incident diabetes
  • Epidemiology
  • Prospective

Brain function and structure and risk for incident diabetes: The Atherosclerosis Risk in Communities Study


Journal Title:

Alzheimer's and Dementia


Volume 13, Number 12


, Pages 1345-1354

Type of Work:

Article | Post-print: After Peer Review


Introduction: Diabetes is prospectively associated with cognitive decline. Whether lower cognitive function and worse brain structure are prospectively associated with incident diabetes is unclear. Methods: We analyzed data for 10,133 individuals with cognitive function testing (1990–1992) and 1212 individuals with brain magnetic resonance imaging (1993–1994) from the Atherosclerosis Risk in Communities cohort. We estimated hazard ratios for incident diabetes through 2014 after adjustment for traditional diabetes risk factors and cohort attrition. Results: Higher level of baseline cognitive function was associated with lower risk for diabetes (per 1 standard deviation, hazard ratio = 0.94; 95% confidence interval = 0.90, 0.98). This association did not persist after accounting for baseline glucose level, case ascertainment methods, and cohort attrition. No association was observed between any brain magnetic resonance imaging measure and incident diabetes. Discussion: This is one of the first studies to prospectively evaluate the association between both cognitive function and brain structure and the incidence of diabetes.

Copyright information:

© 2017 the Alzheimer's Association

This is an Open Access work distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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