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Author Notes:

Address correspondence to: Dr. Chinglai Yang, Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30322, USA, Tel. 404-712-9607, Fax. 404-727-3295, chyang@emory.edu.

The authors in this study have no actual or potential conflict of interest including any financial, personal or other relationships with other people or organizations within three years of beginning the submitted work that could inappropriately influence, or be perceived to influence, their work.

Subjects:

Research Funding:

Portions of this study was supported by funding from the Emory University Global Health Institute, the National Institutes of Health grant AI06652, and the NIH CEIRS contract HHSN272201400004C

Keywords:

  • Science & Technology
  • Life Sciences & Biomedicine
  • Immunology
  • Infectious Diseases
  • Microbiology
  • Influenza
  • Vaccine
  • Aging
  • Regulatory T cell
  • ANTI-CD25 MONOCLONAL-ANTIBODY
  • HUMAN INFECTION
  • INSECT CELLS
  • A VIRUS
  • EFFICACY
  • VACCINES
  • LIVE
  • IMMUNOSENESCENCE
  • VACCINATION
  • EVOLUTION

Blockage of regulatory T cells augments induction of protective immune responses by influenza virus-like particles in aged mice

Tools:

Journal Title:

Microbes and Infection

Volume:

Volume 19, Number 12

Publisher:

, Pages 626-634

Type of Work:

Article | Post-print: After Peer Review

Abstract:

Elderly humans over 65 years old are at great risk to pathogenesis by influenza virus infection. However, although influenza vaccines provide effective protection in healthy young adults, protection of elderly adults is substantially lower even with a good match between the vaccine and the circulating influenza virus. To gain insight of the underlying mechanism for the reduced immunogenicity of influenza vaccines in the aged population, we investigated immunogenicity of influenza virus-like particle vaccines in aged mice, which represent a useful model for studying aging associated impairment in immune responses. Specifically, we investigated the effect of inhibiting regulatory T cells in aged mice on induction of protective immune responses by influenza vaccines. Our results showed that injecting anti-CD25 antibodies could down-regulate CD25 on the surface of regulatory T cells and significantly increase the levels of antibody responses induced by VLP immunization in aged mice. Further, the profiles of antibody responses were also changed towards Th1 type by regulatory T cell blockage in aged mice. Moreover, aged mice that were treated by anti-CD25 antibodies prior to vaccination were more effectively protected against lethal influenza virus challenge.

Copyright information:

© 2017 Institut Pasteur

This is an Open Access work distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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