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Author Notes:

Present address: Division of Neurology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH 45229, USA. Corresponding author: robert.liu@emory.edu

We thank Dr. Edgar Galido-Leon, Dr. Frank G. Lin, and Adam Willats for fruitful discussions.

We thank the staff of Emory University Integrated Cellular Imaging Microscopy Core and especially Neil Anthony for his help in the analysis of 3D-images.

We thank Xiaoyu Xu for help in the classification of Arc-positive cells.

Subjects:

Research Funding:

This work was supported in part by NIDCD R01DC008343 (R.C.L.), NIH training grant 5R90DA033462 (Y.J.K.) and the Emory University Integrated Cellular Imaging Microscopy Core of the Emory Neuroscience NINDS Core Facilities grant, P30NS055077.

Keywords:

  • Science & Technology
  • Social Sciences
  • Life Sciences & Biomedicine
  • Neurosciences
  • Psychology, Experimental
  • Neurosciences & Neurology
  • Psychology
  • ARC MESSENGER-RNA
  • EARLY GENE ARC
  • LONG-TERM POTENTIATION
  • PROTEIN EXPRESSION
  • VISUAL-CORTEX
  • SPATIAL EXPLORATION
  • SYNAPTIC PLASTICITY
  • CORTICAL PLASTICITY
  • NEURONAL ENSEMBLES
  • RAT HIPPOCAMPUS

Familiarity with a vocal category biases the compartmental expression of &ITArc&IT/&ITArg3.1&IT in core auditory cortex

Tools:

Journal Title:

Learning and Memory

Volume:

Volume 24, Number 12

Publisher:

, Pages 612-621

Type of Work:

Article | Final Publisher PDF

Abstract:

Learning to recognize a stimulus category requires experience with its many natural variations. However, the mechanisms that allow a category's sensorineural representation to be updated after experiencing new exemplars are not well understood, particularly at the molecular level. Here we investigate how a natural vocal category induces expression in the auditory system of a key synaptic plasticity effector immediate early gene, Arc/Arg3.1, which is required for memory consolidation. We use the ultrasonic communication system between mouse pups and adult females to study whether prior familiarity with pup vocalizations alters how Arc is engaged in the core auditory cortex after playback of novel exemplars from the pup vocal category. A computerized, 3D surface-assisted cellular compartmental analysis, validated against manual cell counts, demonstrates significant changes in the recruitment of neurons expressing Arc in pup-experienced animals (mothers and virgin females "cocaring" for pups) compared with pup-inexperienced animals (pup-naïve virgins), especially when listening to more familiar, natural calls compared to less familiar but similarly recognized tonal model calls. Our data support the hypothesis that the kinetics of Arc induction to refine cortical representations of sensory categories is sensitive to the familiarity of the sensory experience.

Copyright information:

© 2017 Ivanova et al.

This is an Open Access work distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/).

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