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Author Notes:

Corresponding author at: School of Electrical and Computer Engineering, Georgia Institute of Technology, Atlanta, GA, 30332, United States. stas@gatech.edu

The authors would like to thank Jane Chisholm of the Georgia Institute of Technology for her helpful review of the manuscript.

The authors declare no competing financial interests.


Research Funding:

This work is supported by the National Institutes of Health [CA149740, CA158598] and by the Breast Cancer Research Foundation [BCRF-17-043].


  • Spectroscopic photacoustic imaging
  • Oxygen saturation estimation
  • Optimal wavelength selection
  • Spectral unmixing

Impact of depth-dependent optical attenuation on wavelength selection for spectroscopic photoacoustic imaging


Journal Title:



Volume 12


, Pages 46-54

Type of Work:

Article | Final Publisher PDF


An optical wavelength selection method based on the stability of the absorption cross-section matrix to improve spectroscopic photoacoustic (sPA) imaging was recently introduced. However, spatially-varying chromophore concentrations cause the wavelength- and depth-dependent variations of the optical fluence, which degrades the accuracy of quantitative sPA imaging. This study introduces a depth-optimized method that determines an optimal wavelength set minimizing an inverse of the multiplication of absorption cross-section matrix and fluence matrix to minimize the errors in concentration estimation. This method assumes that the optical fluence distribution is known or can be attained otherwise. We used a Monte Carlo simulation of light propagation in tissue with various depths and concentrations of deoxy-/oxy-hemoglobin. We quantitatively compared the developed and current approaches, indicating that the choice of wavelength is critical and our approach is effective especially when quantifying deeper imaging targets.

Copyright information:

© 2018 The Authors

This is an Open Access work distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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