408 Views | 294 Downloads
Address correspondence to: Theresa Alenghat, 3333 Burnet Ave., MLC 7038, Cincinnati, Ohio, USA. Phone: 513.803.7498; Email: theresa.alenghat@cchmc.org
TA, DK, and LAD designed the studies. DK, VW, SJ, JW, and JM carried out experiments.
DK, MK, YH, RK, and AB assisted with computational analyses.
LAD, BJA, MCD, JSH, JFM, RNB, MCS, TDW, and SK provided patient samples and clinical expertise.
NS, MJR, and MH provided critical reagents and tools.
TA and DK analyzed the data and wrote the manuscript.
We thank the S. Way, D. Haslam, and J. Qualls labs (Infectious Disease, CCHMC) and the H. Deshmukh lab (Pulmonology, CCHMC) for useful discussions and members of the Alenghat lab for critical reading of the manuscript.
The RISK committee provided patient samples and clinical expertise.
We thank CCHMC Veterinary Services, the CCHMC DNA Sequencing Core, and the University of Cincinnati Genomics, Epigenomics, and Sequencing Core for services.
We also thank RISK investigators for patient recruitment and the Crohn’s & Colitis Foundation for RISK support.
Conflict of interest: The authors have declared that no conflict of interest exists.
This research is supported by the National Institutes of Health (DK093784, DK114123, and DK116868 to TA; DK098231 to LAD; and T32 DK007727 to DK), and a Crohn’s & Colitis Foundation/Janssen/AGA award to TA. TA holds a Career Award for Medical Scientists from the Burroughs Wellcome Fund and is a Pew Scholar in the Biomedical Sciences, supported by the Pew Charitable Trust.
This project is supported in part by Public Health Service grant P30 DK078392 and the CCHMC Trustee Award and Procter Scholar’s Program.
© 2018, American Society for Clinical Investigation