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Author Notes:

Correspondence: Kerang Zhang atomsxmu@vip.163.com

GL analyzed the neuroimaging data and wrote the manuscript.

KZ designed this study.

EA wrote and revised the manuscript.

PL and AZ collected the data.

We thank all the volunteers who participated in this study.

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.


Research Funding:

This study is funded by the National Natural Science Foundation of China (No. 81471379), the doctoral foundation of Shanxi Medical University (BS201706), the Postdoctoral Foundation of Shanxi Medical University, and the National key research and development program of China (2016YFC1307103).

EA is funded by the NIH grants 1P50MH100023 and P51OD11132 to YNPRC.


  • Science & Technology
  • Life Sciences & Biomedicine
  • Psychiatry
  • bipolar disorder
  • euthymia
  • amygdala
  • resting state fMRI
  • fALFF
  • FMRI

The Role of Amygdala in Patients With Euthymic Bipolar Disorder During Resting State


Journal Title:

Frontiers in Psychiatry


Volume 9


, Pages 445-445

Type of Work:

Article | Final Publisher PDF


The current study aims to explore the functional changes of the amygdala in patients with euthymic Bipolar Disorder (BD) using resting state fMRI (rs-fMRI). Twenty-one euthymic patients with bipolar disorder and 28 healthy controls participated in this study. Two of the euthymic patients with BD and three of the healthy controls were excluded due to excessive head motion. We found that patients with euthymia (38.79 ± 12.03) show higher fALFF (fractional Amplitude of low-frequency fluctuation) value of the amygdala (t = 2.076, P = 0.044), and lower functional connectivity between the amygdala and supplementary motor area (p < 0.01, GRF corrected) than healthy controls (33.40 ± 8.21). However, euthymic patients did not show a differential activity in ReHo (Regional Homogeneity) and gray matter of the amygdala region as compared to healthy controls. Thus, despite the absence of clinical symptoms in euthymic patients with BD, the amygdala functional activity and its connectivity to other brain regions remain altered. Further investigation of negative emotions and social functioning in euthymic patients with BD are needed and can help pave the way for a better understanding of BD psychopathology.

Copyright information:

© 2018 Li, Liu, Andari, Zhang and Zhang.

This is an Open Access work distributed under the terms of the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/).
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