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Author Notes:
Correspondence: Margaret Heitkemper, Box 357266, University of Washington, Seattle, WA 98195, heit@uw.edu, 206-543-1091.
Subject:
Research Funding:
This work was supported by the National Institute of General Medical Sciences (NIGMS, K01GM109309; Grossmann, PI), the NINR (R01NR013932; Starkweather, PI); (R01NR014800; Dunlop, Corwin, co-PI), the National Institute of Environmental Health Sciences (P30ES019776, an NIH BIRCWH award (K12HD085850), and NIGM (K01GM109309; Grossmann, PI), and NINR (R01NR004142, Heitkemper, PI).
Keywords:
- Science & Technology
- Life Sciences & Biomedicine
- Nursing
- Precision medicine
- Genomics
- Metagenomics
- Metabolomics
- LOW-BACK-PAIN
- PROGRESSIVE MULTIPLE-SCLEROSIS
- IRRITABLE-BOWEL-SYNDROME
- PRETERM BIRTH
- VAGINAL MICROBIOME
- GUT MICROBIOTA
- UNITED-STATES
- PHD PROGRAMS
- METABOLOMICS
- FATIGUE
Biological determinants of health: Genes, microbes, and metabolism exemplars of nursing science
Abstract:
Background Increasingly, nurse scientists are incorporating “omics” measures (e.g., genomics, transcriptomics, proteomics, and metabolomics) in studies of biologic determinants of health and behavior. The role of omics in nursing science can be conceptualized in several ways: (a) as a portfolio of biological measures (biomarkers) to monitor individual risk, (b) as a set of combined data elements that can generate new knowledge based on large and complex patient data sets, (c) as baseline information that promotes health education and potentially personalized interventions, and (d) as a platform to understand how environmental parameters (e.g., diet) interact with the individual's physiology. Purpose In this article, we provide exemplars of nursing scientists who use omics to better understand specific health conditions. Methods We highlight various ongoing nursing research investigations incorporating omics technologies to study chronic pain vulnerability, risk for a pain-related condition, cardiometabolic complications associated with pregnancy, and as biomarkers of response to a dietary intervention. Discussion Omics technologies add an important dimension to nursing science across many foci of investigation. However, there are also challenges and opportunities for nurse scientists who consider using omics in their research. Conclusion The integration of omics holds promise for increasing the impact of nursing research and practice on population health outcomes.
Copyright information:
© 2017 Elsevier Inc.
This is an Open Access work distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (http://creativecommons.org/licenses/by-nc-nd/4.0/).
