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Author Notes:

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Correspondence: Dr. Jose A. Obeso, HM CINAC, Hospital Universitario HM Puerta del Sur, Mostoles, Madrid; Universidad CEU San Pablo, and CIBERNED, Madrid, Spain; jaobeso@movementdisorders.org.

Author Contributions: JAO, MS and JS planned and organized the article.

All other authors wrote specific sections as indicated by names after each sub‐heading.

Disclosures: No relevant conflicts of interests/financial disclosures to report.

Subjects:

Keywords:

  • Science & Technology
  • Life Sciences & Biomedicine
  • Clinical Neurology
  • Neurosciences & Neurology
  • Shaking Palsy
  • Parkinson's disease
  • 200 years anniversary
  • SLEEP BEHAVIOR DISORDER
  • POSITRON-EMISSION-TOMOGRAPHY
  • PROGRESSIVE SUPRANUCLEAR PALSY
  • LEVODOPA-INDUCED DYSKINESIAS
  • MILD COGNITIVE IMPAIRMENT
  • FOCUSED ULTRASOUND THALAMOTOMY
  • PATHOLOGICAL ALPHA-SYNUCLEIN
  • IMPULSE CONTROL DISORDERS
  • MULTIPLE SYSTEM ATROPHY
  • DEEP BRAIN-STIMULATION

Past, Present, and Future of Parkinson's Disease: A Special Essay on the 200th Anniversary of the Shaking Palsy

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Journal Title:

Movement Disorders

Volume:

Volume 32, Number 9

Publisher:

, Pages 1264-1310

Type of Work:

Article | Post-print: After Peer Review

Abstract:

This article reviews and summarizes 200 years of Parkinson's disease. It comprises a relevant history of Dr. James Parkinson's himself and what he described accurately and what he missed from today's perspective. Parkinson's disease today is understood as a multietiological condition with uncertain etiopathogenesis. Many advances have occurred regarding pathophysiology and symptomatic treatments, but critically important issues are still pending resolution. Among the latter, the need to modify disease progression is undoubtedly a priority. In sum, this multiple-author article, prepared to commemorate the bicentenary of the shaking palsy, provides a historical state-of-the-art account of what has been achieved, the current situation, and how to progress toward resolving Parkinson's disease.

Copyright information:

© 2017 International Parkinson and Movement Disorder Society

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