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Correspondence and requests for materials should be addressed to J.L.T. (email: twiss@mailbox.sc.edu)
P.K.S., A.W.E. and J.L.T. designed the study.
Experiments were performed by P.K.S., S.J.L., P.B.J., S.A., A.N.K., S.M.R., T.S., B.S., E.E.T., T.S.H. and A.U., A.L.B., C.J.W., M.F., and A.W.E. provided critical reagents, advanced instrumentation, experimental models, and expert guidance.
E.A.P. provided statistical analyses.
J.L.T. and P.K.S. wrote the manuscript.
All authors commented on the manuscript draft and approved the final version.
The Histochemistry and Tissue Processing Core of Nemours/Alfred I. duPont Hospital performed tissue processing for Children.
M.F. is the incumbent of the Chaya Professorial Chair in Molecular Neuroscience at the Weizmann Institute of Science, and J.L.T. is the incumbent of the SmartState Chair in Childhood Neurotherapeutics at the University of South Carolina.
The authors declare no competing interests.
This work was supported by grant funds from National Institutes of Health (R01-NS041596 and R01-NS089633 to J.L.T. and NS057190 to A.W.E.), Department of Defense—Congressionally Mandated Research Program (W81XWH-2013-1-308 OR120042 to J.L.T. and M.F.), and the Dr. Miriam and Sheldon G. Adelson Medical Research Foundation (to A.L.B., C.J.W., J.L.T., and M.F.).
MS experiments were performed at the Biomedical Mass Spectrometry Resource at UCSF supported by funding from the Howard Hughes Medical Institute (to A.L.B.).
© 2018, The Author(s)