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Author Notes:

Correspondence: Giorgio Bonmassar, giorgio@nmr.mgh.harvard.edu

LaG, JG, JK, and GB conceptualized the study; provided support and guidance with data interpretation.

H-JP designed and performed the NEURON analyses with support from LaG and JK.

NM and LyG designed and performed the animal experiments with support from JK and H-JP. LaG and GB contributed electromagnetic data analysis and visualization software.

FH built the μMS coils.

LaG wrote the manuscript, with contributions from GB and comments from all other authors.

JG provided consulting services for Alpha Omega Co. USA, Inc. and author FH was employed by the company FHC, Inc.

The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Subjects:

Research Funding:

This work was supported by the US National Institutes of Health (NIH) grants R43MH107037 (FH, JG, GB, and JK), R01MH111875 (GB), and K99EB021320 (LaG).

Keywords:

  • Science & Technology
  • Life Sciences & Biomedicine
  • Physiology
  • eddy currents
  • TMS
  • finite element method
  • microcoils
  • inductive stimulation
  • numerical modeling
  • neurostimulation
  • DORSAL COCHLEAR NUCLEUS
  • DEEP-BRAIN-STIMULATION
  • TRANSCRANIAL MAGNETIC STIMULATION
  • NOISE-INDUCED HYPERACTIVITY
  • INTENSE SOUND EXPOSURE
  • INFERIOR COLLICULUS
  • ELECTRIC-FIELDS
  • PARKINSONS-DISEASE
  • ELECTROMAGNETIC INDUCTION
  • PYRAMIDAL NEURONS

Solenoidal Micromagnetic Stimulation Enables Activation o Axons With Specific Orientation

Tools:

Journal Title:

Frontiers in Physiology

Volume:

Volume 9, Number JUL

Publisher:

, Pages 724-724

Type of Work:

Article | Final Publisher PDF

Abstract:

Electrical stimulation of the central and peripheral nervous systems - such as deep brain stimulation, spinal cord stimulation, and epidural cortical stimulation are common therapeutic options increasingly used to treat a large variety of neurological and psychiatric conditions. Despite their remarkable success, there are limitations which if overcome, could enhance outcomes and potentially reduce common side-effects. Micromagnetic stimulation (μMS) was introduced to address some of these limitations. One of the most remarkable properties is that μMS is theoretically capable of activating neurons with specific axonal orientations. Here, we used computational electromagnetic models of the μMS coils adjacent to neuronal tissue combined with axon cable models to investigate μMS orientation-specific properties. We found a 20-fold reduction in the stimulation threshold of the preferred axonal orientation compared to the orthogonal direction. We also studied the directional specificity of μMS coils by recording the responses evoked in the inferior colliculus of rodents when a pulsed magnetic stimulus was applied to the surface of the dorsal cochlear nucleus. The results confirmed that the neuronal responses were highly sensitive to changes in the μMS coil orientation. Accordingly, our results suggest that μMS has the potential of stimulating target nuclei in the brain without affecting the surrounding white matter tracts.

Copyright information:

© 2018 Golestanirad, Gale, Manzoor, Park, Glait, Haer, Kaltenbach and Bonmassar.

This is an Open Access work distributed under the terms of the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/).
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