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Author Notes:

Corresponding author: alon_chen@psych.mpg.de

M. Engel and A.C. conceived and designed the experiments and wrote the manuscript.

M. Engel performed and analyzed most experiments including m6A/m-seq; bioinformatics; m6A-RIP-qPCR; and mouse, behavior, and cell culture experiments. C.E., P.M.K., L.T., and M.R.-H. assisted in experiments.

M.J. performed preliminary experiments with no data used.

S.R. performed bioinformatics analysis of pilot m6A/m-seq experiments not included.

S.G. and J.H.H. generated Mettl3 mice.

C.N. and M.U. performed and analyzed mass spectrometry experiments.

M. Eder performed and analyzed electrophysiological studies.

J.A. and E.B.B. provided human microarray data and clinical samples.

P.W., D.L., C.T.W., M.V.S., J.M.D., and E.B.B. assisted in the design of the project.

The study was supervised by A.C.

We thank T. Namendorf, E. Wagner, B. Hauger, C. Dournes, A. Mederer, A. Ressle, A. Parl, and D. Harbich for their technical support and A. Varga and the animal care team for their devoted assistance with animal care.

We thank S. Karamihalev, M. Filiou, A. Menke, and A. Genewsky for helpful discussions and J. Keverne for professional English editing.

We thank G. Rechavi, S. Moshitch-Moshkovitz, V. Hershkovitz, E. Feldmesser, and G. Stelzer for guidance with preparing and/or analyzing m6A/m-seq libraries and for helpful discussions.

The authors declare no competing interests.

Subjects:

Research Funding:

This work was supported by travel grants from the Boehringer Ingelheim Fonds (M. Engel); the European Research Council (FP7 grant 260463); the Israel Science Foundation (1565/15); the ERANET Program, supported by the Chief Scientist Office of the Israeli Ministry of Health (3-11389); the Federal Ministry of Education and Research (01KU1501A); research support from Roberto and Renata Ruhman and Bruno and Simone Licht; the I-CORE Program of the Planning and Budgeting Committee and the Israel Science Foundation (1916/12); the Nella and Leon Benoziyo Center for Neurological Diseases; the Henry Chanoch Krenter Institute for Biomedical Imaging and Genomics; the Perlman Family Foundation; the Adelis Foundation; the Irving I. Moskowitz Foundation (all previous to A.C.); the Israel Science Foundation (355/17 and 107/14, J.H.H); and FAMRI and NYSCF grants (J.H.H).

Keywords:

  • Science & Technology
  • Life Sciences & Biomedicine
  • Neurosciences
  • Neurosciences & Neurology
  • MESSENGER-RNA METHYLATION
  • OBESITY-ASSOCIATED GENE
  • NUCLEAR-RNA
  • FAT MASS
  • R/BIOCONDUCTOR PACKAGE
  • PSYCHIATRIC-DISORDERS
  • PREFRONTAL CORTEX
  • SEQ DATA
  • BRAIN
  • FTO

The Role of m(6)A/m-RNA Methylation in Stress Response Regulation

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Journal Title:

Neuron

Volume:

Volume 99, Number 2

Publisher:

, Pages 389-+

Type of Work:

Article | Final Publisher PDF

Copyright information:

© 2018 The Author(s)

This is an Open Access work distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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