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Author Notes:

Address correspondence to D. Ye, 1518 Clifton Rd. NE, CNR 2036, Atlanta, GA 30322 USA. Telephone: (203) 848-0225. Email: dongni.ye@emory.edu

The authors acknowledge the contributions of members of the Southeastern Center for Air Pollution and Epidemiology (SCAPE) research group.

This publication is based in part upon information obtained from the Georgia Hospital Association and individual hospitals; we are grateful for the support of all participating hospitals.

The content of this publication is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health or the U.S. EPA.

Further, the U.S. EPA does not endorse the purchase of any commercial products or services mentioned in the publication.

Subjects:

Research Funding:

Research reported in this publication was supported by funding from the Electric Power Research Institute (EPRI, 10002467).

This publication was also made possible by a Clean Air Research Center grant to Emory University and the Georgia Institute of Technology from the U.S. Environmental Protection Agency (EPA, RD834799), as well as by grants to Emory University from the U.S. EPA (R82921301), the National Institute of Environmental Health Sciences (R01ES11294), and the EPRI (EP-P27723/C13172 and EP-P4353/C2124).

Keywords:

  • Science & Technology
  • Life Sciences & Biomedicine
  • Environmental Sciences
  • Public, Environmental & Occupational Health
  • Toxicology
  • Environmental Sciences & Ecology
  • PARTICULATE MATTER CONSTITUENTS
  • EMERGENCY-DEPARTMENT VISITS
  • MED-PARTICLES PROJECT
  • TIME-SERIES ANALYSIS
  • NEW-YORK-CITY
  • AIR-POLLUTION
  • HOSPITAL ADMISSIONS
  • CHEMICAL-COMPOSITION
  • RESPIRATORY-DISEASES
  • SOURCE-APPORTIONMENT

Estimating Acute Cardiovascular Effects of Ambient PM2.5 Metals

Tools:

Journal Title:

Environmental Health Perspectives

Volume:

Volume 126, Number 2

Publisher:

, Pages 027007-027007

Type of Work:

Article | Final Publisher PDF

Abstract:

BACKGROUND: Few epidemiologic studies have investigated health effects of water-soluble fractions of PM2.5metals, the more biologically accessible fractions of metals, in their attempt to identify health-relevant components of ambient PM2.5. OBJECTIVES: In this study, we estimated acute cardiovascular effects of PM2.5components in an urban population, including a suite of water-soluble metals that are not routinely measured at the ambient level. METHODS: Ambient concentrations of criteria gases, PM2.5, and PM2.5components were measured at a central monitor in Atlanta, Georgia, during 1998–2013, with some PM2.5components only measured during 2008–2013. In a time-series framework using Poisson regression, we estimated associations between these pollutants and daily counts of emergency department (ED) visits for cardiovascular diseases in the five-county Atlanta area. RESULTS: Among the PM2.5components we examined during 1998–2013, water-soluble iron had the strongest estimated effect on cardiovascular outcomes [RR =1.012 (95% CI: 1.005, 1.019), per interquartile range increase (20.46 ng/m3)]. The associations for PM2.5and other PM2.5components were consistent with the null when controlling for water-soluble iron. Among PM2.5components that were only measured during 2008–2013, water-soluble vanadium was associated with cardiovascular ED visits [RR =1.012 (95% CI: 1.000, 1.025), per interquartile range increase (0.19 ng/m3)]. CONCLUSIONS: Our study suggests cardiovascular effects of certain water-soluble metals, particularly water-soluble iron. The observed associations with water-soluble iron may also point to certain aspects of traffic pollution, when processed by acidifying sulfate, as a mixture harmful for cardiovascular health.

Copyright information:

EHP is an open-access journal published with support from the National Institute of Environmental Health Sciences, National Institutes of Health. All content is public domain unless otherwise noted.

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