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Author Notes:

Corresponding author. Storm Eye Institute, Medical University of South Carolina, 167 Ashley Ave, Charleston, SC, 29425. E-mail address: magrath@musc.edu (G.N. Magrath).

Verbal consent was obtained for the publication of this paper from the patient's legal guardian.

All patient identifiers were excluded.

No conflicting relationship exists for any author.

The authors do not have any commercial or proprietary interest in the product or company discussed (BCG, NAW, MJN, LAB, SLC, MA, HG, GNM).

George Magrath, M.D. has had full access to all the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.

The funders had no role in the design and conduct of the study, in the collection, analysis and interpretation of the data, and in the preparation, review or approval of the manuscript.


Research Funding:

Support provided by an unrestricted grant from the Foundation Fighting Blindness and the South Carolina Lion's Club.


  • Glaucoma
  • Iris melanoma
  • Pediatric

Iris melanoma presenting as childhood glaucoma


Journal Title:

American Journal of Ophthalmology Case Reports


Volume 11


, Pages 56-60

Type of Work:

Article | Final Publisher PDF


Purpose: To describe the natural history and management of a rare case of iris melanoma in a pediatric patient. Observations: A Caucasian female presented with left pupillary abnormalities at age 7, progressive iris changes at age 9, and markedly elevated intraocular pressure with advanced optic nerve cupping at 11 years of age. She was found to have a pigmented lesion overlying her iris and invading her angle. Trans-corneal fine needle aspirate biopsy demonstrated malignant melanoma of the iris. The patient subsequently underwent Iodine-125 plaque brachytherapy for the tumor. Conclusions: and Importance: Early identification and treatment of iris melanoma may be associated with decreased risk of local progression and metastatic disease. Treatment of glaucoma in conjunction with uveal melanoma is complicated by tumor specific considerations, including treatment of the tumor and prevention of metastasis.

Copyright information:

© 2018 Elsevier B.V. or its licensors or contributors.

This is an Open Access work distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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