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Author Notes:

Corresponding author: S.B. Blakey, sblakey@emory.edu

We thank Dr John Bacsa and the Emory X-Ray Center for X-ray structural analysis.

Subject:

Research Funding:

This research was supported by the National Science Foundation under the Center for Chemical Innovation in Selective C–H Functionalization (CHE1205646).

Keywords:

  • Science & Technology
  • Physical Sciences
  • Chemistry, Multidisciplinary
  • Chemistry
  • BOND ACTIVATION
  • NATURAL-PRODUCTS
  • INSERTION
  • COMPLEXES
  • CYCLOPROPANATION
  • CARBENOIDS
  • LIGANDS
  • RHODIUM

Iridium(III)-bis(imidazolinyl)phenyl catalysts for enantioselective C-H functionalization with ethyl diazoacetate

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Journal Title:

Chemical Science

Volume:

Volume 7, Number 5

Publisher:

, Pages 3142-3146

Type of Work:

Article | Final Publisher PDF

Abstract:

The intermolecular enantioselective C-H functionalization with acceptor-only metallocarbenes is reported using a new family of Ir(iii)-bis(imidazolinyl)phenyl catalysts, developed based on the interplay of experimental and computational insights. The reaction is tolerant of a variety of diazoacetate precursors and is found to be heavily influenced by the steric and electronic properties of the substrate. Phthalan and dihydrofuran derivatives are functionalized in good yields and excellent enantioselectivities.

Copyright information:

© 2016 The Royal Society of Chemistry.

This is an Open Access work distributed under the terms of the Creative Commons Attribution 3.0 Unported License (http://creativecommons.org/licenses/by/3.0/).

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