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Author Notes:

Correspondence Contact: Samara Eberlin, Rua Sandoval Meirelles, 72, Vila João Jorge, Campinas, SP, Brazil, 13.041-315, Phone: +55 19 3829-3482, samara@kosmoscience.com.

Conflict of Interest: Adilson Costa: none, Gustavo Facchini: none, Ana Lúcia T. A. Pinheiro: none, Michelle Sabrina da Silva: none, Michael Yi Bonner: none, Jack Arbiser: none, Samara Eberlin: none

Subjects:

Research Funding:

Jack Arbiser, M.D., Ph.D. is funded in part by NIH RO1AR47901.

Keywords:

  • Science & Technology
  • Life Sciences & Biomedicine
  • Dermatology
  • ARYL-HYDROCARBON RECEPTOR
  • NECROSIS-FACTOR-ALPHA
  • WEIGHT NATURAL-PRODUCT
  • FIBROBLASTS IN-VITRO
  • KAPPA-B ACTIVATION
  • OXIDATIVE STRESS
  • CYCLE ARREST
  • HUMAN KERATINOCYTES
  • SIGNALING PATHWAY
  • MAGNOLIA-OBOVATA

Honokiol protects skin cells against inflammation, collagenolysis, apoptosis, and senescence caused by cigarette smoke damage

Tools:

Journal Title:

International Journal of Dermatology

Volume:

Volume 56, Number 7

Publisher:

, Pages 754-761

Type of Work:

Article | Post-print: After Peer Review

Abstract:

Background: Pollution, especially cigarette smoke, is a major cause of skin damage. Objectives: To assess the effects of the small molecule polyphenol, honokiol, on reversing cigarette smoke-induced damage in vitro to relevant skin cells. Methods: Keratinocytes (HaCat) cultures were exposed to cigarette smoke and, after 48 hours, IL-1α and IL-8 were measured in cell supernatants. Moreover, TIMP-2 production, apoptosis rate, and senescence β-galactosidase expression were evaluated in primary human foreskin fibroblasts (HFF-1) cultures. Results: Honokiol at 10 μm reduced IL-1α production by 3.4 folds (P < 0.05) and at 10 and 20 μm reduced IL-8 by 23.9% and 53.1% (P < 0.001), respectively, in HaCat keratinocytes. In HFF-1, honokiol restored TIMP-2 production by 96.9% and 91.9% (P < 0.001), respectively, at 10 and 20 μm, as well as reduced apoptosis by 47.1% (P < 0.001) and 41.3% (P < 0.01), respectively. Finally, honokiol reduced senescence-associated β-galactosidase expression in HFF-1. Conclusion: Honokiol protects both HFF-1 and HaCat against cigarette smoke-induced inflammation, collagenolysis, apoptosis, and senescence.

Copyright information:

© 2017 The International Society of Dermatology

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