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Author Notes:

Corresponding Author: Gretchen N. Neigh, PhD, Virginia Commonwealth University, 1101 East Marshall Street, PO Box 980709, Richmond, VA 23298, V: 804-628-5152, F: 804-828-9477, gretchen.mccandless@vcuhealth.org

These authors contributed equally to this work.

The authors have no conflicting interests.

Subjects:

Research Funding:

The authors receive funding from NIH: NR014886 and MH110364. SAR was supported by NIH training grant T32-GM008602.

Keywords:

  • Science & Technology
  • Life Sciences & Biomedicine
  • Endocrinology & Metabolism
  • Neurosciences
  • Neurosciences & Neurology
  • Glucocorticoid receptor
  • Nuclear factor kappa-light-chain-enhancer of activated B cells
  • Stress
  • Depression
  • Anxiety
  • PTSD
  • FKBP5
  • Inflammation
  • Glucocorticoid resistance
  • ACTIVATED PROTEIN-KINASE
  • MAJOR DEPRESSIVE DISORDER
  • PEPTIDYLPROLYL ISOMERASE DOMAIN
  • STEROID-BINDING CONFORMATION
  • OXIDE SYNTHASE EXPRESSION
  • BLOOD MONONUCLEAR-CELLS
  • HIPPOCAMPAL HT22 CELLS
  • PITUITARY-ADRENAL AXIS
  • SEX-DEPENDENT MANNER
  • HEAT-SHOCK-PROTEIN

Checks and balances: The glucocorticoid receptor and NF kappa B in good times and bad

Tools:

Journal Title:

Frontiers in Neuroendocrinology

Volume:

Volume 46

Publisher:

, Pages 15-31

Type of Work:

Article | Post-print: After Peer Review

Abstract:

Mutual regulation and balance between the endocrine and immune systems facilitate an organism's stress response and are impaired following chronic stress or prolonged immune activation. Concurrent alterations in stress physiology and immunity are increasingly recognized as contributing factors to several stress-linked neuropsychiatric disorders including depression, anxiety, and post-traumatic stress disorder. Accumulating evidence suggests that impaired balance and crosstalk between the glucocorticoid receptor (GR) and nuclear factor kappa-light-chain-enhancer of activated B cells (NFκB) – effectors of the stress and immune axes, respectively – may play a key role in mediating the harmful effects of chronic stress on mood and behavior. Here, we first review the molecular mechanisms of GR and NFκB interactions in health, then describe potential shifts in the GR-NFκB dynamics in chronic stress conditions within the context of brain circuitry relevant to neuropsychiatric diseases. Furthermore, we discuss developmental influences and sex differences in the regulation of these two transcription factors.

Copyright information:

© 2017 Elsevier Inc.

This is an Open Access work distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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