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Author Notes:

Address correspondence to: Veronica Vieira, D.Sc., Program in Public Health, University of California, Irvine, 653 E. Peltason Dr., Irvine, CA, 92697-3957, USA; vvieria@uci.edu; (949)824-7017.

Its contents are solely the responsibility of the authors and do not necessarily represent the views of NIH.

All authors have indicated they have no financial relationships relevant to this article to disclose.

The authors have no conflicts of interest relevant to this article to disclose.


Research Funding:

This work was supported by grant number 5R01ES019897 from the National Institute of Environmental Health (NIEHS).

This work was partially supported by NASA Applied Sciences Program (grant no. NNX11AI53G to Y.L and X.H).


  • Science & Technology
  • Life Sciences & Biomedicine
  • Environmental Sciences
  • Public, Environmental & Occupational Health
  • Toxicology
  • Environmental Sciences & Ecology
  • LIFE

Exposure to acute air pollution and risk of bronchiolitis and otitis media for preterm and term infants


Journal Title:

Journal of Exposure Science and Environmental Epidemiology


Volume 28, Number 4


, Pages 348-357

Type of Work:

Article | Post-print: After Peer Review


Our aim is to estimate associations between acute increases in particulate matter with diameter of 2.5 μm or less (PM2.5) concentrations and risk of infant bronchiolitis and otitis media among Massachusetts births born 2001 through 2008.Our case-crossover study included 20,017 infant bronchiolitis and 42,336 otitis media clinical encounter visits. PM2.5was modeled using satellite, remote sensing, meteorological and land use data. We applied conditional logistic regression to estimate odds ratios (ORs) and confidence intervals (CIs) per 10-μg/m3increase in PM2.5.We assessed effect modification to determine the most susceptible subgroups. Infant bronchiolitis risk was elevated for PM2.5exposure 1 day (OR = 1.07, 95% CI = 1.03-1.11) and 4 days (OR = 1.04, 95% CI = 0.99-1.08) prior to clinical encounter, but not 7 days. Non-significant associations with otitis media varied depending on lag. Preterm infants were at substantially increased risk of bronchiolitis 1 day prior to clinical encounter (OR = 1.17, 95% CI = 1.08-1.28) and otitis media 4 and 7 days prior to clinical encounter (OR = 1.09, 95% CI = 1.02-1.16 and OR = 1.08, 95% CI = 1.02-1.15, respectively). In conclusion, preterm infants are most susceptible to infant bronchiolitis and otitis media associated with acute PM2.5exposures.

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© 2017 The Author(s).

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