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Author Notes:

Corresponding author: Jennifer F. Kawwass, jennifer.kawwass@emory.edu



  • Science & Technology
  • Life Sciences & Biomedicine
  • Public, Environmental & Occupational Health

Strategies for Preventing HIV Infection Among HIV-Uninfected Women Attempting Conception with HIV-Infected Men - United States


Journal Title:

MMWR. Morbidity and mortality weekly report


Volume 66, Number 21


, Pages 554-557

Type of Work:

Article | Final Publisher PDF


What is already known about this topic? For HIV-discordant couples (in which the man is HIV-infected and the woman is not HIV-infected) who wish to conceive a biological child, strategies to minimize the risk for sexual transmission are needed. In 1990, CDC recommended against insemination with semen from HIV-infected men. What is added by this report? Recent data regarding the safety of semen processing suggest that such processing is a viable option for HIV discordant couples attempting conception. The risk for transmission from an HIV-infected man to an HIV-negative woman is low if appropriate risk-reduction strategies, such as the use of highly active antiretroviral therapy, antiretroviral preexposure prophylaxis, and sperm washing are implemented. Recent evidence suggests that discordant couples might consider condomless intercourse timed to coincide with ovulation or intrauterine insemination of the woman or in vitro fertilization in combination with sperm washing after discussing the risks and benefits of each option with a medical provider. What are the implications for public health practice? As further data emerge, the risk profile for each treatment option will be further defined. HIV-discordant couples who desire to conceive might wish to discuss treatment options with a medical provider who can explain the risks and benefits of different treatment modalities as they apply to the couple’s specific situation before attempting conception.

Copyright information:

© 2017, Department of Health and Human Services. All rights reserved.

This is an Open Access work distributed under the terms of the Creative Commons Universal : Public Domain Dedication License (http://creativecommons.org/publicdomain/zero/1.0/).

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