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Author Notes:

Correspondence: Andrew N. Young: andrew.n.young@emory.edu

Academic Editor: Peter E. Clark

Subjects:

Keywords:

  • Science & Technology
  • Life Sciences & Biomedicine
  • Environmental Sciences
  • Multidisciplinary Sciences
  • Environmental Sciences & Ecology
  • Science & Technology - Other Topics
  • kidney neoplasms
  • gene expression profiling
  • microarrays
  • CANCER-SPECIFIC SURVIVAL
  • GENE-EXPRESSION DATA
  • COMPLEMENTARY-DNA MICROARRAY
  • SOLITARY BONY METASTASIS
  • CELL CARCINOMA PATIENTS
  • EPITHELIAL NEOPLASMS
  • OSSEOUS METASTASES
  • SURGICAL-TREATMENT
  • KIDNEY CANCER
  • PROGNOSTIC STRATIFICATION

Current trends in the molecular classification of renal neoplasms

Tools:

Journal Title:

Scientific World Journal

Volume:

Volume 6

Publisher:

, Pages 2505-2518

Type of Work:

Article | Final Publisher PDF

Abstract:

Renal cell carcinoma (RCC) is the most common form of kidney cancer in adults. RCC is a significant challenge for pathologic diagnosis and clinical management. The primary approach to diagnosis is by light microscopy, using the World Health Organization (WHO) classification system, which defines histopathologic tumor subtypes with distinct clinical behavior and underlying genetic mutations. However, light microscopic diagnosis of RCC subtypes is often difficult due to variable histology. In addition, the clinical behavior of RCC is highly variable and therapeutic response rates are poor. Few clinical assays are available to predict outcome in RCC or correlate behavior with histology. Therefore, novel RCC classification systems based on gene expression should be useful for diagnosis, prognosis, and treatment. Recent microarray studies have shown that renal tumors are characterized by distinct gene expression profiles, which can be used to discover novel diagnostic and prognostic biomarkers. Here, we review clinical features of kidney cancer, the WHO classification system, and the growing role of molecular classification for diagnosis, prognosis, and therapy of this disease.

Copyright information:

© 2006 Andrew N. Young et al.

This is an Open Access work distributed under the terms of the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/).
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