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Author Notes:

Correspondence: Peng Jin: pjin@genetics.emory.edu

Academic Editors: D. Shurtleff and S. Ferre

Subjects:

Keywords:

  • Animals
  • Fragile X Mental Retardation Protein
  • Humans
  • Intellectual Disability
  • MicroRNAs
  • Neurons

Role of microRNA pathway in mental retardation

Tools:

Journal Title:

Scientific World Journal

Volume:

Volume 7, Number SUPPL. 2

Publisher:

, Pages 146-154

Type of Work:

Article | Final Publisher PDF

Abstract:

Deficits in cognitive functions lead to mental retardation (MR). Understanding the genetic basis of inherited MR has provided insights into the pathogenesis of MR. Fragile X syndrome is one of the most common forms of inherited MR, caused by the loss of functional Fragile X Mental Retardation Protein (FMRP). MicroRNAs (miRNAs) are endogenous, single-stranded RNAs between 18 and 25 nucleotides in length, which have been implicated in diversified biological pathways. Recent studies have linked the miRNA pathway to fragile X syndrome. Here we review the role of the miRNA pathway in fragile X syndrome and discuss its implication in MR in general.

Copyright information:

© 2007 Abrar Qurashi et al.

This is an Open Access work distributed under the terms of the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/).
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