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Author Notes:

CORRESPONDING AUTHOR: Shishir K. Maithel, MD, 1365C Clifton Rd. NE, Building C, 2nd floor, Atlanta, GA 30322, Office: 404-778-5777, Fax: 404-778-4255, smaithe@emory.edu

This paper was presented as an Oral Presentation at the International Hepato-Pancreato-Biliary Association 12th World Congress, held April 20 – 23, 2016 in Sao Paulo, Brazil.




  • Science & Technology
  • Life Sciences & Biomedicine
  • Oncology
  • Surgery
  • high-grade dysplasia
  • ovarian stroma
  • surgical resection

The diagnosis of pancreatic mucinous cystic neoplasm and associated adenocarcinoma in males: An eight-institution study of 349 patients over 15 years

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Journal Title:

Journal of Surgical Oncology


Volume 115, Number 7


, Pages 784-787

Type of Work:

Article | Post-print: After Peer Review


BACKGROUND: Per WHO, 2000 classification, pancreatic mucinous cystic neoplasms (MCN) are defined by presence of ovarian stroma, and are primarily located in the pancreatic body/tail of females. The incidence of MCN and associated malignancy in males, since, standardization of MCN diagnostic-criteria is unknown. METHODS: MCN resections from 2000 to 2014 at eight institutions of the Central-Pancreas-Consortium were included, and divided into early (2000-2007) and late (2008-2014) time-periods. Primary aim was to characterize MCN and associated adenocarcinoma/high-grade-dysplasia (AC/HGD) in males versus females over time. RESULTS: Of 1667 resections for pancreatic cystic lesions, 349 pts (21%) had MCNs: 310 (89%) female, 39 (11%) male. Patients were equally divided between early (n = 173) and late (n = 176) time-periods. MCN in male-patients decreased over time (early: 15%, late: 7%; P = 0.036), as did pancreatic head/neck location (early: 22%, late: 11%; P = 0.01). MCN-associated AC/HGD was more frequent in males versus females (39 vs. 12%; P < 0.001). The overall rate of MCN-associated AC/HGD remained stable (early: 17%, late: 13%; P = 0.4), and was identical in males (39%) over both time-periods. Males with AC/HGD had more LN-positive disease versus females (57 vs. 22%; P = 0.039). CONCLUSIONS: As the diagnostic-criteria of MCN have standardized over time, MCN diagnosis has decreased in males and head/neck location. Despite this, MCN-associated adenocarcinoma/high-grade dysplasia has been stable and remains high in males. Any male with suspected MCN, regardless of location, should undergo resection.

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© 2017 Wiley Periodicals, Inc.

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