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Author Notes:

Email: mcelroya@pitt.edu

We would like to thank Patrick Tusime, Health Officer for Kabale District for his assistance, and Tanya Klimova for editing the manuscript.

The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

The views and opinions expressed in this manuscript are those of the authors and do not represent the official position of the US Centers for Disease Control and Prevention.

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Research Funding:

AKM is supported by an NIH K08 AI119448, and a Burroughs Wellcome Career Award for Medical Scientists #1013362.01.

This work was also supported by Children's Healthcare of Atlanta Pediatric Research Trust Startup Funds to AKM.

Keywords:

  • ADAMTS13 Protein
  • Adolescent
  • Biomarkers
  • Blood Coagulation
  • Cytokines
  • Hemorrhage
  • Humans
  • Male
  • Middle Aged
  • P-Selectin
  • Rift Valley Fever
  • Rift Valley fever virus
  • Viral Load
  • Young Adult

Rift valley fever viral load correlates with the human inflammatory response and coagulation pathway abnormalities in humans with hemorrhagic manifestations.

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Journal Title:

PLoS Neglected Tropical Diseases

Volume:

Volume 12, Number 5

Publisher:

, Pages e0006460-e0006460

Type of Work:

Article | Final Publisher PDF

Abstract:

Rift Valley fever virus is an arbovirus that affects both livestock and humans throughout Africa and in the Middle East. Despite its endemicity throughout Africa, it is a rare event to identify an infected individual during the acute phase of the disease and an even rarer event to collect serial blood samples from the affected patient. Severely affected patients can present with hemorrhagic manifestations of disease. In this study we identified three Ugandan men with RVFV disease that was accompanied by hemorrhagic manifestations. Serial blood samples from these men were analyzed for a series of biomarkers specific for various aspects of human pathophysiology including inflammation, endothelial function and coagulopathy. There were significant differences between biomarker levels in controls and cases both early during the illness and after clearance of viremia. Positive correlation of viral load with markers of inflammation (IP-10, CRP, Eotaxin, MCP-2 and Granzyme B), markers of fibrinolysis (tPA and D-dimer), and markers of endothelial function (sICAM-1) were all noted. However, and perhaps most interesting given the fact that these individuals exhibited hemorrhagic manifestations of disease, was the finding of a negative correlation between viral load and P-selectin, ADAMTS13, and fibrinogen all of which are associated with coagulation pathways occurring on the endothelial surface.

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This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

This is an Open Access work distributed under the terms of the Creative Commons Universal : Public Domain Dedication License (http://creativecommons.org/publicdomain/zero/1.0/).

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