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Author Notes:

Dr. Lilia De Jesus – ldejesus@med.wayne.edu, tel. 313-7455638, fax. 313-7455867.

We are indebted to our medical and nursing colleagues and the infants and their parents who agreed to take part in this study.

See publication for full list of members of the Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network.

Data collected at participating sites of the NICHD Neonatal Research Network were transmitted to RTI International, the data coordinating center for the network, which stored, managed, and analyzed the data for this study.

The authors declare no conflicts of interest.


Research Funding:

Supported by grants from the National Institutes of Health and the National Institute of Child Health and Human Development (NICHD) for the Neonatal Research Network’s Generic Database and Follow-up Studies.


  • Science & Technology
  • Life Sciences & Biomedicine
  • Pediatrics

Risk Factors for Post-NICU Discharge Mortality Among Extremely Low Birth Weight Infants


Journal Title:

Journal of Pediatrics


Volume 161, Number 1


, Pages 70-+

Type of Work:

Article | Post-print: After Peer Review


Objective: The study goal was to evaluate maternal and neonatal risk factors associated with post-neonatal intensive care unit (NICU) discharge mortality among extremely low birth weight (ELBW) infants. Study design: This is a retrospective analysis of ELBW (<1000 g) and <27 weeks' gestational age infants born in the Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network sites between January 2000 and June 2007. Infants were tracked until death or 18 to 22 months' corrected age. Infants who died between NICU discharge and the 18- to 22-month follow-up visit were classified as post-NICU discharge mortality (P-NDM). Association of maternal and infant risk factors with P-NDM was determined using logistic regression analysis. A prediction model with 6 significant predictors was developed and validated. Results: There were 5364 infants who survived to NICU discharge; 557 (10%) infants were lost to follow-up, and 107 infants died following NICU discharge. P-NDM rate was 22.3 per 1000 ELBW infants. In the prediction model, African American race, unknown maternal health insurance, and hospital stay ≥120 days significantly increased risk, and maternal exposure to intrapartum antibiotics was associated with decreased risk of P-NDM. Conclusion: We identified African American race, unknown medical insurance, and prolonged NICU stay as risk factors associated with P-NDM among ELBW infants.

Copyright information:

© 2012 Mosby Inc. All rights reserved.

This is an Open Access work distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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