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Author Notes:

Douglas L. Rosene, PhD, Dept. of Anatomy & Neurobiology, Boston University School of Medicine, 700 Albany St., W701, Boston, MA 02127, Email: drosene@bu.edu.

Subjects:

Research Funding:

Grant sponsor: National Institutes of Health (NIH); Grant numbers: P01-AG000001, P51-RR000165, R37-AG17609, and R01-MH69686.

Keywords:

  • Science & Technology
  • Life Sciences & Biomedicine
  • Neurosciences
  • Zoology
  • Neurosciences & Neurology
  • glia number
  • hypothalamus volume
  • paraventricular nucleus (PVN)
  • sexual dimorphism
  • AGE-RELATED-CHANGES
  • RAT SUPRACHIASMATIC NUCLEUS
  • SEXUALLY DIMORPHIC NUCLEUS
  • ALZHEIMERS-DISEASE
  • HUMAN-BRAIN
  • PARAVENTRICULAR NUCLEUS
  • VENTROMEDIAL NUCLEUS
  • COGNITIVE DECLINE
  • MACACA-MULATTA
  • MORPHOMETRIC ANALYSIS

Neuron Numbers in the Hypothalamus of the Normal Aging Rhesus Monkey: Stability Across the Adult Lifespan and Between the Sexes

Tools:

Journal Title:

Journal of Comparative Neurology

Volume:

Volume 520, Number 6

Publisher:

, Pages 1181-1197

Type of Work:

Article | Post-print: After Peer Review

Abstract:

Normal aging is accompanied by changes in hypothalamic functions including autonomic and endocrine functions and circadian rhythms. The rhesus monkey provides an excellent model of normal aging without the potential confounds of incipient Alzheimer's disease inherent in human populations. This study examined the hypothalamus of 51 rhesus monkeys (23 male, 18 female, 6.5-31 years old) using design-based stereology to obtain unbiased estimates of neuron and glia numbers and the Cavalieri method to estimate volumes for eight reference spaces: total unilateral hypothalamus, suprachiasmatic nucleus (SCN), supraoptic nucleus (SON), paraventricular nucleus (PVN), dorsomedial nucleus (DM), ventromedial nucleus (VM), medial mammillary nucleus (MMN), and lateral hypothalamic area (LHA). The results demonstrated no age-related difference in neuron number, glia number, or volume in any area in either sex except the PVN of male monkeys, which showed a significant increase in both neuron and glia numbers with age. Comparison of males and females for sexual dimorphisms revealed no significant differences in neuron number. However, males had more glia overall as well as in the SCN, DM, and LHA and had a larger hypothalamic volume overall and in the SCN, SON, VM, DM, and MMN. These results demonstrate that hypothalamic neuron loss cannot account for age-related deficits in hypothalamic function and provides further evidence of the absence of neurodegeneration and cell death in the normal aging rhesus monkey.

Copyright information:

© 2011 Wiley Periodicals, Inc.

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